Søren S Olesen1,2, Louise Kuhlmann1,2,3, Srdan Novovic4, Camilla Nøjgaard4, Evangelos Kalaitzakis5, Nanna M Jensen6, Trond Engjom7,8, Georg Dimcevski7, Anne Waage9, Stephan L Haas10, Miroslav Vujasinovic10, Romualdas Riauka11, Aldis Pukitis12, Imanta Ozola-Zālīte12, Alexey Okhlobystin13, Mikael Parhiala14,15, Johanna Laukkarinen14,15, Asbjørn M Drewes1,2. 1. Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark. 2. Clinical Institute, Aalborg University, Aalborg, Denmark. 3. Department of Internal Medicine, North Denmark Regional Hospital, Hjørring, Denmark. 4. Department of Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark. 5. Copenhagen University Hospital/Herlev, University of Copenhagen, Copenhagen, Denmark. 6. Abdominalcenter K, Bispebjerg Hospital, Copenhagen, Denmark. 7. Department of Clinical Medicine, University of Bergen, Bergen, Norway. 8. Department of Medicine, Haukeland University Hospital, Bergen, Norway. 9. Department of Surgery, Oslo University Hospital, Oslo, Norway. 10. Centre for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden. 11. Department of Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania. 12. Centre of Gastroenterology, Hepatology and Nutrition, Pauls Stradiņš Clinical University Hospital, Riga, Latvia. 13. Medical Faculty, Sechenov First Moscow State Medical University, Moscow, Russia. 14. Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland. 15. Cancer Center, Faculty of Medicine and Heath Technology, Tampere University, Tampere, Finland.
Abstract
BACKGROUND AND AIM: Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number of patient and disease characteristics. However, the complex interrelations of these parameters are incompletely understood, and pain treatment remains unsatisfactory in a large proportion of patients. The aim of this study is to investigate multiple pain risk factors in a large population of CP patients, with a special emphasis on patients' patterns of smoking and alcohol use. METHODS: This was a multicenter, cross-sectional study including 1384 patients with CP. Patient demographics and disease characteristics, as well as current patterns of smoking and alcohol use, were compared for patients with pain (n = 801) versus without pain (n = 583). Multivariate logistic regression models were performed to assess the variables associated with the presence and type of pain (constant vs intermittent pain). RESULTS: The mean age of participants was 52.1 ± 14.6 years, and 914 (66%) were men. Active smoking (odds ratio 1.6 [95% confidence interval 1.1-2.2], P = 0.005) and alcohol consumption (odds ratio 1.8 [95% confidence interval 1.1-3.0], P = 0.03) were independently associated with the presence of pain. In addition, patients' age at diagnosis, pancreatic duct pathology, and the presence of pseudocysts, duodenal stenosis, and exocrine pancreatic insufficiency were confirmed as pain risk factors (all P ≤ 0.01). Constant pain, as opposed to intermittent pain, was more frequently reported by smokers (P = 0.03), while alcohol consumption was associated with intermittent pain (P = 0.006). CONCLUSION: Multiple patient and disease characteristics, including patterns of smoking and alcohol consumption, associate with the presence and type of pain in patients with CP.
BACKGROUND AND AIM: Pain is the primary symptom of chronic pancreatitis (CP) and associates with a number of patient and disease characteristics. However, the complex interrelations of these parameters are incompletely understood, and pain treatment remains unsatisfactory in a large proportion of patients. The aim of this study is to investigate multiple pain risk factors in a large population of CP patients, with a special emphasis on patients' patterns of smoking and alcohol use. METHODS: This was a multicenter, cross-sectional study including 1384 patients with CP. Patient demographics and disease characteristics, as well as current patterns of smoking and alcohol use, were compared for patients with pain (n = 801) versus without pain (n = 583). Multivariate logistic regression models were performed to assess the variables associated with the presence and type of pain (constant vs intermittent pain). RESULTS: The mean age of participants was 52.1 ± 14.6 years, and 914 (66%) were men. Active smoking (odds ratio 1.6 [95% confidence interval 1.1-2.2], P = 0.005) and alcohol consumption (odds ratio 1.8 [95% confidence interval 1.1-3.0], P = 0.03) were independently associated with the presence of pain. In addition, patients' age at diagnosis, pancreatic duct pathology, and the presence of pseudocysts, duodenal stenosis, and exocrine pancreatic insufficiency were confirmed as pain risk factors (all P ≤ 0.01). Constant pain, as opposed to intermittent pain, was more frequently reported by smokers (P = 0.03), while alcohol consumption was associated with intermittent pain (P = 0.006). CONCLUSION: Multiple patient and disease characteristics, including patterns of smoking and alcohol consumption, associate with the presence and type of pain in patients with CP.
Authors: Samuel Y Han; Darwin L Conwell; Philip T Diaz; Amy Ferketich; Christie Y Jeon; Dhiraj Yadav; Phil A Hart Journal: Pancreatology Date: 2022-08-11 Impact factor: 3.977
Authors: Jami L Saloman; Gong Tang; Kimberly M Stello; Kristen E Hall; Xianling Wang; Samer AlKaade; Peter A Banks; Randall E Brand; Darwin L Conwell; Gregory A Coté; Christopher E Forsmark; Timothy B Gardner; Andres Gelrud; Michele D Lewis; Stuart Sherman; Adam Slivka; David C Whitcomb; Dhiraj Yadav Journal: Pancreatology Date: 2021-09-30 Impact factor: 3.996
Authors: Søren S Olesen; Laust H Mortensen; Elisabeth Zinck; Ulrik Becker; Asbjørn M Drewes; Camilla Nøjgaard; Srdan Novovic; Dhiraj Yadav; Janne S Tolstrup Journal: United European Gastroenterol J Date: 2021-02-22 Impact factor: 4.623