Literature DB >> 31313595

Thiazole in the targeted anticancer drug discovery.

Adileh Ayati1, Saeed Emami2, Setareh Moghimi1, Alireza Foroumadi1,3.   

Abstract

Cancer is known as one of the main causes of death in the world; and many compounds have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile heterocycle, found in the structure of many drugs in use as well as anticancer agents. This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells. Chemical designs, structure-activity relationships and relevant preclinical properties have been comprehensively described.

Entities:  

Keywords:  anticancer agents; cancer; drug discovery; signaling pathways; thiazole; tumor cells

Mesh：

Substances：

Year:  2019        PMID： 31313595     DOI： 10.4155/fmc-2018-0416

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  6 in total

Review 1.  Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances.

Authors:  Khaled Mahmoud; Shady Swidan; Mohamed El-Nabarawi; Mahmoud Teaima
Journal:  J Nanobiotechnology       Date:  2022-03-05       Impact factor: 10.435

2.  Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights.

Authors:  Tarfah Al-Warhi; Ahmed M El Kerdawy; Mohamed A Said; Amgad Albohy; Zainab M Elsayed; Nada Aljaeed; Eslam B Elkaeed; Wagdy M Eldehna; Hatem A Abdel-Aziz; Miral A Abdelmoaz
Journal:  Drug Des Devel Ther       Date:  2022-05-16       Impact factor: 4.319

Review 3.  An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives.

Authors:  Anca-Maria Borcea; Ioana Ionuț; Ovidiu Crișan; Ovidiu Oniga
Journal:  Molecules       Date:  2021-01-25       Impact factor: 4.411

4.  Synthesis of aspirin-curcumin mimic conjugates of potential antitumor and anti-SARS-CoV-2 properties.

Authors:  Aladdin M Srour; Siva S Panda; Ahmed Mostafa; Walid Fayad; May A El-Manawaty; Ahmed A F Soliman; Yassmin Moatasim; Ahmed El Taweel; Mohamed F Abdelhameed; Mohamed S Bekheit; Mohamed A Ali; Adel S Girgis
Journal:  Bioorg Chem       Date:  2021-11-04       Impact factor: 5.275

5.  Novel 1,3-Thiazole Analogues with Potent Activity against Breast Cancer: A Design, Synthesis, In Vitro, and In Silico Study.

Authors:  Manar G Salem; Dina M Abu El-Maaty; Yassmina I Mohey El-Deen; Basem H Elesawy; Ahmad El Askary; Asmaa Saleh; Essa M Saied; Mohammed El Behery
Journal:  Molecules       Date:  2022-07-31       Impact factor: 4.927

6.  Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors.

Authors:  Guangcheng Wang; Wenjing Liu; Meiyan Fan; Min He; Yongjun Li; Zhiyun Peng
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051
  6 in total

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