A Clinical, Biochemical Profile of Type-2 Diabetes in Women with Special Reference to Vitamin-D Status in Obese and Non-Obese.

INTRODUCTION: Type-2 Diabetes is a heterogeneous group of disorders characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased glucose production. Obese diabetic patients have 13.5% more chances of developing diabetic complications compared to non - obese diabetic patients. Vitamin D has found to be deficient in diabetic patient and it's role in insulin regulation. Obese females are more prone to develop diabetic complications and hypovitaminosis-D. MATERIALS AND
METHOD: Total of 156 female diabetic patients aged 30 to 60 years who are a case of type-2 diabetes mellitus seen in Rajarajeswari Medical College and Hospital were clinically evaluated including anthropometric measurements are done, namely height, weight, waist-hip ratio, tested for vitamin-D levels and other necessary diabetes related investigations were carried out. RESULT: Among the studies 156 patients, Mean age of study group: 48.47±9.56 years. Mean duration of diabetes in the study population: ± SD: 5.10±4.36 years mean BMI was 24.97±4.16.Mean waist circumference: 98.93±12.18 cm, Mean Waist-Hip ratio: 0.98±0.08. Mean FBS: 202.73±81.73 mg/dl, Mean PPBS: 280.99±94.14 mg/dl, Mean HbA1C: 9.33±1.83 %. Almost all diabetic females (92.5%) have Vitamin-D deficiency. Mean Vitamin-D levels: 16.19±8.97 ng/ml. Duration of diabetes (P=0.082+, Fisher Exact test), Poor Glycemic control (P<0.001**, Chi-Square test) and increased BMI (P=0.011*, Fisher Exact test) had significant role in causing Vitamin-D deficiency.
CONCLUSION: Almost all diabetic females were with Waist circumference > 80 cm and Waist-Hip ratio > 0.8. Most of the diabetic patients have poor control of diabetes. Vitamin-D deficiency is found in almost all diabetic female patients (92.5%) and the most probable cause is poor glycemic control and obesity according to this study. © Journal of the Association of Physicians of India 2011.