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Literature DB >> 31309761

[Research progress on miR-21 in heart diseases].

Abstract

Pathological processes such as myocardial apoptosis, cardiac hypertrophy, myocardial fibrosis, and cardiac electrical remodeling are involved in the development and progression of most cardiac diseases. MicroRNA-21 (miR-21) has been found to play an important role in heart diseases as a novel type of endogenous regulators, which can inhibit cardiomyocyte apoptosis, improve hypertension and cardiac hypertrophy, promote myocardial fibrosis and atrial electrical remodeling. In this review, we summarize the research progress on the function of miR-21 in heart diseases and its mechanism, and discuss its potential application in diagnosis and treatment of heart diseases.

Entities: Chemical

Mesh：

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Year: 2019 PMID： 31309761 PMCID： PMC8800808 DOI： 10.3785/j.issn.1008-9292.2019.04.14

Source DB: PubMed Journal: Zhejiang Da Xue Xue Bao Yi Xue Ban ISSN： 1008-9292

40 in total

1. Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.

Authors: Yunhui Cheng; Ping Zhu; Jian Yang; Xiaojun Liu; Shimin Dong; Xiaobin Wang; Bao Chun; Jian Zhuang; Chunxiang Zhang
Journal: Cardiovasc Res Date: 2010-03-10 Impact factor: 10.787

2. miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats.

Authors: Vitalina Gryshkova; Alisha Fleming; Portia McGhan; Pierrette De Ron; Renaud Fleurance; Jean-Pierre Valentin; Andre Nogueira da Costa
Journal: Toxicol Lett Date: 2018-01-31 Impact factor: 4.372

Review 3. Epigenetic mechanisms in heart development and disease.

Authors: Shannalee R Martinez; Maresha S Gay; Lubo Zhang
Journal: Drug Discov Today Date: 2015-01-06 Impact factor: 7.851

4. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

Authors: Thomas Thum; Carina Gross; Jan Fiedler; Thomas Fischer; Stephan Kissler; Markus Bussen; Paolo Galuppo; Steffen Just; Wolfgang Rottbauer; Stefan Frantz; Mirco Castoldi; Jürgen Soutschek; Victor Koteliansky; Andreas Rosenwald; M Albert Basson; Jonathan D Licht; John T R Pena; Sara H Rouhanifard; Martina U Muckenthaler; Thomas Tuschl; Gail R Martin; Johann Bauersachs; Stefan Engelhardt
Journal: Nature Date: 2008-11-30 Impact factor: 49.962

5. Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.

Authors: Adriana Barana; Marcos Matamoros; Pablo Dolz-Gaitón; Marta Pérez-Hernández; Irene Amorós; Mercedes Núñez; Sandra Sacristán; Álvaro Pedraz; Ángel Pinto; Francisco Fernández-Avilés; Juan Tamargo; Eva Delpón; Ricardo Caballero
Journal: Circ Arrhythm Electrophysiol Date: 2014-08-08

6. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

Authors: Johan M Lorenzen; Celina Schauerte; Anika Hübner; Malte Kölling; Filippo Martino; Kristian Scherf; Sandor Batkai; Karina Zimmer; Ariana Foinquinos; Tamas Kaucsar; Jan Fiedler; Regalla Kumarswamy; Claudia Bang; Dorothee Hartmann; Shashi K Gupta; Jan Kielstein; Andreas Jungmann; Hugo A Katus; Frank Weidemann; Oliver J Müller; Hermann Haller; Thomas Thum
Journal: Eur Heart J Date: 2015-04-21 Impact factor: 29.983

1. MiRNA-21 Regulates Bronchial Epithelial Cell Proliferation by Activating Tgfβ1/Smad Signaling Pathway and Its Correlation with Asthma Severity in Children.

Authors: Yang Kang; Minghui Bai; Liling Deng; Linbo Fan; Xing Wang
Journal: Iran J Public Health Date: 2021-10 Impact factor: 1.429

1 in total

[Research progress on miR-21 in heart diseases].

1. Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4.

2. miR-21-5p as a potential biomarker of inflammatory infiltration in the heart upon acute drug-induced cardiac injury in rats.

Review 3. Epigenetic mechanisms in heart development and disease.

4. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

5. Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.

6. Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis.

7. miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting Jagged1.

8. Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy.

9. Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4.

Review 10. Evolutionary Patterns of Non-Coding RNA in Cardiovascular Biology.

1. MiRNA-21 Regulates Bronchial Epithelial Cell Proliferation by Activating Tgfβ1/Smad Signaling Pathway and Its Correlation with Asthma Severity in Children.