Efthymios Papadopoulos1,2, Shabbir M H Alibhai3,4,5, George A Tomlinson4,5,6, Andrew G Matthew4,5, Michael Nesbitt7, Antonio Finelli4,7, John Trachtenberg4,7, Daniel Santa Mina8,3,4. 1. Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada. efthymios.papadopoulos@mail.utoronto.ca. 2. Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, Canada. efthymios.papadopoulos@mail.utoronto.ca. 3. Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, Canada. 4. Faculty of Medicine, University of Toronto, Toronto, ON, Canada. 5. Department of Medicine, University Health Network, Toronto, ON, Canada. 6. Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada. 7. Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada. 8. Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada.
Abstract
PURPOSE: Epidemiologic data suggest that high levels of physical activity (PA) may reduce the risk of disease progression in men with prostate cancer (PCa), but it is unknown whether PA can delay the requirement for definitive treatment for those on active surveillance (AS). We investigated the influence of PA post-diagnosis on AS discontinuation in men with low-risk disease. METHODS: The effect of PA on the time to AS discontinuation was assessed in 421 patients, of whom 107 underwent additional PCa treatment over a median of 2.5 years. RESULTS: Using Cox regression models, we found that PA was not significantly associated with time to curative treatment initiation. Prostate-specific antigen (PSA) most proximal to AS initiation (HR, 1.11; 95% CI 1.03 to 1.21) and the number of positive cores (HR, 1.34; 95% CI 1.12 to 1.61) at diagnosis were associated with a significantly increased risk of discontinuing AS. CONCLUSION: Our findings suggest that PA during AS for PCa does not significantly influence time to curative treatment.
PURPOSE: Epidemiologic data suggest that high levels of physical activity (PA) may reduce the risk of disease progression in men with prostate cancer (PCa), but it is unknown whether PA can delay the requirement for definitive treatment for those on active surveillance (AS). We investigated the influence of PA post-diagnosis on AS discontinuation in men with low-risk disease. METHODS: The effect of PA on the time to AS discontinuation was assessed in 421 patients, of whom 107 underwent additional PCa treatment over a median of 2.5 years. RESULTS: Using Cox regression models, we found that PA was not significantly associated with time to curative treatment initiation. Prostate-specific antigen (PSA) most proximal to AS initiation (HR, 1.11; 95% CI 1.03 to 1.21) and the number of positive cores (HR, 1.34; 95% CI 1.12 to 1.61) at diagnosis were associated with a significantly increased risk of discontinuing AS. CONCLUSION: Our findings suggest that PA during AS for PCa does not significantly influence time to curative treatment.
Entities:
Keywords:
Active surveillance; Low-risk disease; Physical activity; Prostate cancer; Treatment
Authors: Julika Loss; Nicola Brew-Sam; Boris Metz; Helmut Strobl; Alexandra Sauter; Susanne Tittlbach Journal: Int J Environ Res Public Health Date: 2020-03-30 Impact factor: 3.390