Literature DB >> 31307989

The tva(A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli.

Ana B García-Martín1,2, Sybille Schwendener1, Vincent Perreten3.   

Abstract

The tva(A) gene suspected to confer resistance to pleuromutilins in Brachyspira hyodysenteriae was tested for functionality in Escherichia coli AG100A and Staphylococcus aureus RN4220. Expression of the cloned tva(A) gene conferred decreased susceptibility to pleuromutilin (P) and streptogramin A (SA) antibiotics in E. coli and had a minor effect in S. aureus The finding provides evidence of the direct association of tva(A) with the PSA resistance phenotype.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  ABC-F protein; antibiotic resistance; gene expression; pristinamycin IIA; swine dysentery; tiamulin; valnemulin; virginiamycin M1

Mesh：

Substances：

Year:  2019        PMID： 31307989      PMCID： PMC6709466          DOI： 10.1128/AAC.00930-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Transposon-associated lincosamide resistance lnu(C) gene identified in Brachyspira hyodysenteriae ST83.

Authors:  Silvio De Luca; Pamela Nicholson; Chiara F Magistrali; Ana B García-Martín; Lorenz Rychener; Friederike Zeeh; Joachim Frey; Vincent Perreten
Journal:  Vet Microbiol       Date:  2017-12-07       Impact factor: 3.293

2.  New shuttle vector-based expression system to generate polyhistidine-tagged fusion proteins in Staphylococcus aureus and Escherichia coli.

Authors:  Sybille Schwendener; Vincent Perreten
Journal:  Appl Environ Microbiol       Date:  2015-03-06       Impact factor: 4.792

3.  AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.

Authors:  H Okusu; D Ma; H Nikaido
Journal:  J Bacteriol       Date:  1996-01       Impact factor: 3.490

4.  Genetic basis of macrolide and lincosamide resistance in Brachyspira (Serpulina) hyodysenteriae.

Authors:  M Karlsson; C Fellström; M U Heldtander; K E Johansson; A Franklin
Journal:  FEMS Microbiol Lett       Date:  1999-03-15       Impact factor: 2.742

5.  Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain.

Authors:  Álvaro Hidalgo; Ana Carvajal; Birte Vester; Märit Pringle; Germán Naharro; Pedro Rubio
Journal:  Antimicrob Agents Chemother       Date:  2011-05-09       Impact factor: 5.191

6.  Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin.

Authors:  Frank Schlünzen; Erez Pyetan; Paola Fucini; Ada Yonath; Jörg M Harms
Journal:  Mol Microbiol       Date:  2004-12       Impact factor: 3.501

7.  Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

Authors:  Märit Pringle; Jacob Poehlsgaard; Birte Vester; Katherine S Long
Journal:  Mol Microbiol       Date:  2004-12       Impact factor: 3.501

Review 8.  Antimicrobial resistance in Brachyspira - An increasing problem for disease control.

Authors:  David J Hampson; Kittitat Lugsomya; Tom La; Nyree Dale Phillips; Darren J Trott; Sam Abraham
Journal:  Vet Microbiol       Date:  2018-12-17       Impact factor: 3.293

9.  Improved method for electroporation of Staphylococcus aureus.

Authors:  S Schenk; R A Laddaga
Journal:  FEMS Microbiol Lett       Date:  1992-07-01       Impact factor: 2.742

10.  Mutations in the 50S ribosomal subunit of Brachyspira hyodysenteriae associated with altered minimum inhibitory concentrations of pleuromutilins.

Authors:  Sonja Hillen; Hermann Willems; Werner Herbst; Judith Rohde; Gerald Reiner
Journal:  Vet Microbiol       Date:  2014-05-05       Impact factor: 3.293
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  1 in total

1.  Whole-genome analyses reveal a novel prophage and cgSNPs-derived sublineages of Brachyspira hyodysenteriae ST196.

Authors:  Ana Belén García-Martín; Thomas Roder; Sarah Schmitt; Friederike Zeeh; Rémy Bruggmann; Vincent Perreten
Journal:  BMC Genomics       Date:  2022-02-15       Impact factor: 3.969
  1 in total

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