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Literature DB >> 31307983

Inhibition of Chikungunya Virus Replication in Primary Human Fibroblasts by Liver X Receptor Agonist.

Jesse Hwang¹, Yuchen Wang², Erol Fikrig^2,3.

Abstract

The mosquito-borne chikungunya virus (CHIKV) causes acute pain and joint inflammation, and in recent years the virus has caused large epidemics in previously CHIKV-free geographic areas. To advance the understanding of host factors that antagonize CHIKV, we show that synthetic agonist of liver X receptor (LXR-623) inhibits CHIKV replication by upregulating the cholesterol exporter ABCA1 and that endogenous and pharmacological activation of interferon signaling pathway partners with LXR-623 to generate a superior antiviral state.

Entities: Chemical Disease Gene Species

Keywords: LXR; chikungunya; host-targeting antiviral; virus

Mesh：

Substances：

Year: 2019 PMID： 31307983 PMCID： PMC6709483 DOI： 10.1128/AAC.01220-19

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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5 in total

Review 1. Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins.

Authors: Shijie Mao; Jie Ren; Ying Xu; Jidong Lin; Chuqiao Pan; Yu Meng; Ning Xu
Journal: Eur J Pharmacol Date: 2022-05-19 Impact factor: 5.195