Pattiya Nutthachote1, Shina Oranratanaphan2, Wichai Termrungruanglert3, Surang Triratanachat4, Arkom Chaiwongkot5, Fern Baedyananda6, Parvapan Bhattarakosol7. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: kwannarak_26@hotmail.com. 2. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: dr_shina@hotmail.com. 3. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: wichaiterm@yahoo.com. 4. Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. Electronic address: t_surang@hotmail.co.th. 5. Department of Microbiology, Faculty of Medicine, Chulalongkorn University, 10330, Thailand. Electronic address: arkomchaiwongkot@gmail.com. 6. Department of Microbiology, Faculty of Medicine, Chulalongkorn University, 10330, Thailand. Electronic address: fbaedyan@gmail.com. 7. Department of Microbiology, Faculty of Medicine, Chulalongkorn University, 10330, Thailand. Electronic address: bhparvapan@gmail.com.
Abstract
OBJECTIVE: to correlate the detection rate of high risk HPV (HR-HPV) DNA between self-collected and clinician-collected testing. MATERIALS AND METHODS: A cross-sectional analytic study was conducted in 400 women undergoing cervical cancer screening program during February and May 2015. The procedure began with self-collected method and then clinician-collected method. Then, the specimens were processed and interpreted with the same technique. If the results from either methods were positive for HPV genotype 16 or 18, colposcopy was performed. We also conducted cytology testing for the participants. If the results were abnormal (ASC-US+), colposcopy was also performed. RESULTS: The detection rate of HR-HPV DNA was 10.0% and 7.5% by self-collected and clinician-collected specimen, respectively (kappa = 0.73). HR-HPV positive rate in cytology ASC-US+ was no significantly different between groups. HR-HPV DNAs were positive in every HSIL (100% detection rate). HPV DNA test positive for detection CIN+ was not significantly different between self-collected and clinician-collected testing. CONCLUSION: self-collected HPV testing can be used as an alternative option for primary cervical screening program. Detection rate of high grade lesion is similar to clinician-collected test.
OBJECTIVE: to correlate the detection rate of high risk HPV (HR-HPV) DNA between self-collected and clinician-collected testing. MATERIALS AND METHODS: A cross-sectional analytic study was conducted in 400 women undergoing cervical cancer screening program during February and May 2015. The procedure began with self-collected method and then clinician-collected method. Then, the specimens were processed and interpreted with the same technique. If the results from either methods were positive for HPV genotype 16 or 18, colposcopy was performed. We also conducted cytology testing for the participants. If the results were abnormal (ASC-US+), colposcopy was also performed. RESULTS: The detection rate of HR-HPV DNA was 10.0% and 7.5% by self-collected and clinician-collected specimen, respectively (kappa = 0.73). HR-HPV positive rate in cytology ASC-US+ was no significantly different between groups. HR-HPV DNAs were positive in every HSIL (100% detection rate). HPV DNA test positive for detection CIN+ was not significantly different between self-collected and clinician-collected testing. CONCLUSION: self-collected HPV testing can be used as an alternative option for primary cervical screening program. Detection rate of high grade lesion is similar to clinician-collected test.
Authors: Chia-Hao Liu; Yu-Chieh Lee; Jeff Chien-Fu Lin; I-San Chan; Na-Rong Lee; Wen-Hsun Chang; Wei-Min Liu; Peng-Hui Wang Journal: Int J Environ Res Public Health Date: 2019-10-11 Impact factor: 3.390
Authors: Bernardo Vega Crespo; Vivian Alejandra Neira; José Ortíz Segarra; Ruth Maldonado Rengel; Diana López; María Paz Orellana; Andrea Gómez; María José Vicuña; Jorge Mejía; Ina Benoy; Tesifón Parrón Carreño; Veronique Verhoeven Journal: Int J Environ Res Public Health Date: 2022-04-12 Impact factor: 4.614