The potential exposure and hazards of copper nanoparticles: A review.

Copper is an essential element for metabolism in plants and animals. In its nanoform, copper has found various applications, thus increasing potential environmental exposure. Released nanoparticles in the environment undergo various transformation processes while bioaccumulation and toxicity of copper nanoparticles have been demonstrated in plants and animals. This toxicity is thought to be a combined effect of intracellular particles and the release of dissolved copper ions. Oxidative stress responses have been studied in copper nanoparticle induced effects as well as other pathways to cytotoxicity. The antimicrobial potential of copper nanoparticles makes them excellent components for application in biomedicine and more recently, they have been investigated for applications as drug delivery agents in cancer therapy. These properties of copper nanoparticles necessitate a thorough review and understanding of toxic mechanisms of action and the associated implications of exposure to human and environmental health.