Yulan Lin1, Chuancheng Wu2,3, Wei Yan4, Saixiong Guo5, Su Lin6, Baoying Liu2,3. 1. Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China. 2. Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China. 3. Fujian Provincial Key Laboratory of Environment Factors and Cancer, Fujian Medical University, Fuzhou, China. 4. Fujian Xianyou Health and Family Planning Authority, Putian, China. 5. Fujian Xianyou County Hospital, Putian, China. 6. Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Abstract
Objectives: To explore the role of sociodemographic and lifestyle factors in the development of gastric cancer in a high-risk region of China. Methods: In a case-control study, all newly diagnosed patients with gastric cancer were compared with healthy controls matched (1:1) by sex, age (±3 years), and place of residence during 2013-2017. Results: A total of 622 gastric cancer and 622 healthy controls were included. Larger household size (>4 family members) appeared to decrease gastric cancer risk for Helicobacter pylori-negative ones (odd ratio = 0.43, 95% CI = 0.26-0.70). Similarly, longer refrigerator ownership was associated with a 67% decreased risk in H. pylori-negative group (95% CI = 0.15-0.77). Participants with a family history of gastric cancer had nearly fivefold higher risk (odd ratio = 4.88, 95% CI = 2.49-9.55). Smoking attributed to 83% increased risk (odd ratio = 1.83, 95% CI = 1.19-2.80). Tea consumption dramatically decreased risk in whole study population (odd ratio = 0.28, 95% CI = 0.17-0.45).Conclusions: In summary, family history, smoking, H. pylori-related chronic atrophic gastritis, and H. pylori infection were positively associated with gastric cancer. Whereas, tea consumption and refrigerator use negatively associated with gastric cancer and could be promoted to reduce gastric cancer rate in high-risk populations, especially in the developing regions.
Objectives: To explore the role of sociodemographic and lifestyle factors in the development of gastric cancer in a high-risk region of China. Methods: In a case-control study, all newly diagnosed patients with gastric cancer were compared with healthy controls matched (1:1) by sex, age (±3 years), and place of residence during 2013-2017. Results: A total of 622 gastric cancer and 622 healthy controls were included. Larger household size (>4 family members) appeared to decrease gastric cancer risk for Helicobacter pylori-negative ones (odd ratio = 0.43, 95% CI = 0.26-0.70). Similarly, longer refrigerator ownership was associated with a 67% decreased risk in H. pylori-negative group (95% CI = 0.15-0.77). Participants with a family history of gastric cancer had nearly fivefold higher risk (odd ratio = 4.88, 95% CI = 2.49-9.55). Smoking attributed to 83% increased risk (odd ratio = 1.83, 95% CI = 1.19-2.80). Tea consumption dramatically decreased risk in whole study population (odd ratio = 0.28, 95% CI = 0.17-0.45).Conclusions: In summary, family history, smoking, H. pylori-related chronic atrophic gastritis, and H. pyloriinfection were positively associated with gastric cancer. Whereas, tea consumption and refrigerator use negatively associated with gastric cancer and could be promoted to reduce gastric cancer rate in high-risk populations, especially in the developing regions.
Authors: Georgia Martimianaki; Gianfranco Alicandro; Claudio Pelucchi; Rossella Bonzi; Matteo Rota; Jinfu Hu; Kenneth C Johnson; Charles S Rabkin; Linda M Liao; Rashmi Sinha; Zuo-Feng Zhang; Michela Dalmartello; Nuno Lunet; Samantha Morais; Domenico Palli; Monica Ferraroni; Guo-Pei Yu; Shoichiro Tsugane; Akihisa Hidaka; Maria Paula Curado; Emmanuel Dias-Neto; David Zaridze; Dmitry Maximovitch; Jesus Vioque; Manoli Garcia de la Hera; Lizbeth López-Carrillo; Raúl Ulises Hernández-Ramírez; Gerson Shigueaki Hamada; Mary H Ward; Lina Mu; Reza Malekzadeh; Farhad Pourfarzi; Antonia Trichopoulou; Anna Karakatsani; Robert C Kurtz; Areti Lagiou; Pagona Lagiou; Stefania Boccia; Paolo Boffetta; M Constanza Camargo; Eva Negri; Carlo La Vecchia Journal: Br J Cancer Date: 2022-05-24 Impact factor: 9.075