| Literature DB >> 31304985 |
Tjasa Lepko1,2,3, Melanie Pusch1, Tamara Müller4, Dorothea Schulte4, Janina Ehses5, Michael Kiebler5, Julia Hasler1, Hagen B Huttner6, Roosmarijn E Vandenbroucke7,8,9, Charysse Vandendriessche7,8,9, Miha Modic10,11, Ana Martin-Villalba12, Sheng Zhao12, Enric LLorens-Bobadilla12, Anja Schneider13,14, Andre Fischer15, Christopher T Breunig16,17, Stefan H Stricker16,17, Magdalena Götz1,3,18, Jovica Ninkovic1,3,5,18.
Abstract
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.Entities:
Keywords: adult neurogenesis; miR-204; neural stem cells; neurogenesis; neurogenic priming
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Year: 2019 PMID： 31304985 PMCID： PMC6717894 DOI： 10.15252/embj.2018100481
Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598