Y Nakamura 1 , Z Liu 1 , S Fukumoto 1 , K Shinoda 1 , A Sakoda 1 , T Matsushita 1 , S Hayashida 1 , N Isobe 2 , M Watanabe 1 , A Hiwatashi 3 , R Yamasaki 1 , J-I Kira 1 Show Affiliations »
Abstract
BACKGROUND AND PURPOSE: The cervical and thoracic cross-sectional spinal cord area (CS-SCA) in multiple sclerosis (MS) correlates with disability, whilst such a correlation remains to be established in neuromyelitis optica spectrum disorder (NMOSD). Our aim was to clarify differences between MS and NMOSD in spinal cord segments where CS-SCA is associated with disability. METHODS: The CS-SCA at C2/C3, C3/C4, T8/T9 and T9/T10 vertebral disc levels was measured in 140 MS patients (111 with relapsing-remitting MS and 29 with progressive MS) and 42 NMOSD patients with anti-aquaporin-4 immunoglobulin G. Disability was evaluated by Expanded Disability Status Scale (EDSS) scores. Multivariate associations between CS-SCA and disability were assessed by stepwise forward multiple linear regression. RESULTS: Thoracic CS-SCA was significantly smaller in NMOSD patients than in MS patients even after adjusting for age, sex and disease duration (P = 0.002 at T8/T9), whilst there was no difference in cervical CS-SCA between the two diseases. Cervical and thoracic CS-SCA had a negative correlation with EDSS scores in MS patients (P < 0.0001 at C3/C4 and P = 0.0002 at T8/T9) whereas only thoracic CS-SCA correlated with EDSS scores in NMOSD patients (P = 0.0006 at T8/T9). By multiple regression analyses, predictive factors for disability in MS were smaller cervical CS-SCA, progressive course, older age and a higher number of relapses, whilst those in NMOSD were smaller thoracic CS-SCA and older age. CONCLUSIONS: Thoracic CS-SCA is a useful predictive marker for disability in patients with NMOSD whilst cervical CS-SCA is associated with disability in patients with MS. © European Academy of Neurology 2019.
BACKGROUND AND PURPOSE: The cervical and thoracic cross-sectional spinal cord area (CS -SCA) in multiple sclerosis (MS) correlates with disability, whilst such a correlation remains to be established in neuromyelitis optica spectrum disorder (NMOSD). Our aim was to clarify differences between MS and NMOSD in spinal cord segments where CS -SCA is associated with disability. METHODS: The CS -SCA at C2/C3, C3/C4 , T8/T9 and T9/T10 vertebral disc levels was measured in 140 MS patients (111 with relapsing-remitting MS and 29 with progressive MS) and 42 NMOSD patients with anti-aquaporin-4 immunoglobulin G. Disability was evaluated by Expanded Disability Status Scale (EDSS) scores. Multivariate associations between CS -SCA and disability were assessed by stepwise forward multiple linear regression. RESULTS: Thoracic CS -SCA was significantly smaller in NMOSD patients than in MS patients even after adjusting for age, sex and disease duration (P = 0.002 at T8/T9), whilst there was no difference in cervical CS -SCA between the two diseases. Cervical and thoracic CS -SCA had a negative correlation with EDSS scores in MS patients (P < 0.0001 at C3/C4 and P = 0.0002 at T8/T9) whereas only thoracic CS -SCA correlated with EDSS scores in NMOSD patients (P = 0.0006 at T8/T9). By multiple regression analyses, predictive factors for disability in MS were smaller cervical CS -SCA, progressive course, older age and a higher number of relapses, whilst those in NMOSD were smaller thoracic CS -SCA and older age. CONCLUSIONS: Thoracic CS -SCA is a useful predictive marker for disability in patients with NMOSD whilst cervical CS -SCA is associated with disability in patients with MS. © European Academy of Neurology 2019.
Entities: Chemical
Disease
Gene
Species
Keywords:
Expanded Disability Status Scale (EDSS) score; multiple sclerosis; neuromyelitis optica spectrum disorders; spinal cord area
Mesh： See more »
Year: 2019
PMID： 31304648 DOI： 10.1111/ene.14038
Source DB: PubMed Journal: Eur J Neurol ISSN： 1351-5101 Impact factor: 6.089