D Barbato1, F Castellani1, A Angelozzi1, C Isonne1, V Baccolini1, G Migliara1, C Marzuillo1, C De Vito1, P Villari2, F Romano3, M De Giusti2. 1. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. 2. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy - Hospital Hygiene Unit, Policlinico Umberto I Hospital, Rome, Italy. 3. Health Directorate, Policlinico Umberto I Hospital, Rome, Italy.
Abstract
BACKGROUND: Healthcare-associated infection (HAI) is the most frequent adverse event in healthcare settings. It is associated with increased mortality and antimicrobial resistance, leading to prolonged hospital stays and consistent financial loss for healthcare systems. The objective of this study was to estimate the burden of HAIs and antimicrobial use in the Teaching Hospital Policlinico Umberto I (THPUI) of Rome and to identify the most critical areas for intervention. METHODS: Data were collected according to the most recent ECDC point prevalence survey protocol in November 2018. Descriptive statistics for all variables were calculated. Univariate analysis was used to assess possible associations between variables and HAIs. Variables with a significance level of p<0.25 were included in a multiple logistic regression model. RESULTS: A total of 799 patients were included in the analysis; of these, 13.3% presented with at least one HAI. Bloodstream infection was the most common, accounting for 30.9% of total infections. Overall, 125 microorganisms were isolated, with Enterobacteriaceae being the most frequent (32%). At the time of the survey, 49.1% patients were receiving antimicrobial therapy. The multivariate analysis showed a significant association between HAI and use of medical devices (OR=34.30; 95% CI:3.69-318.66), length of stay (OR=1.01; 95% CI:1.00-1.02) and exposure to prophylactic antimicrobial therapy (OR=0.23; 95% CI:0.11-0.47). CONCLUSIONS: The ECDC methodology proved to be applicable to THPUI, where HAI prevalence was higher than the European standard (6.7%). This highlights the need to implement targeted measures to prevent and control HAIs, including continuous monitoring to evaluate the effectiveness of such interventions.
BACKGROUND: Healthcare-associated infection (HAI) is the most frequent adverse event in healthcare settings. It is associated with increased mortality and antimicrobial resistance, leading to prolonged hospital stays and consistent financial loss for healthcare systems. The objective of this study was to estimate the burden of HAIs and antimicrobial use in the Teaching Hospital Policlinico Umberto I (THPUI) of Rome and to identify the most critical areas for intervention. METHODS: Data were collected according to the most recent ECDC point prevalence survey protocol in November 2018. Descriptive statistics for all variables were calculated. Univariate analysis was used to assess possible associations between variables and HAIs. Variables with a significance level of p<0.25 were included in a multiple logistic regression model. RESULTS: A total of 799 patients were included in the analysis; of these, 13.3% presented with at least one HAI. Bloodstream infection was the most common, accounting for 30.9% of total infections. Overall, 125 microorganisms were isolated, with Enterobacteriaceae being the most frequent (32%). At the time of the survey, 49.1% patients were receiving antimicrobial therapy. The multivariate analysis showed a significant association between HAI and use of medical devices (OR=34.30; 95% CI:3.69-318.66), length of stay (OR=1.01; 95% CI:1.00-1.02) and exposure to prophylactic antimicrobial therapy (OR=0.23; 95% CI:0.11-0.47). CONCLUSIONS: The ECDC methodology proved to be applicable to THPUI, where HAI prevalence was higher than the European standard (6.7%). This highlights the need to implement targeted measures to prevent and control HAIs, including continuous monitoring to evaluate the effectiveness of such interventions.
Authors: Hugo Teixeira; Alberto Freitas; António Sarmento; Paulo Nossa; Hernâni Gonçalves; Maria de Fátima Pina Journal: Int J Environ Res Public Health Date: 2021-04-28 Impact factor: 3.390
Authors: Claudia Isonne; Valentina Baccolini; Giuseppe Migliara; Mariateresa Ceparano; Francesco Alessandri; Giancarlo Ceccarelli; Guglielmo Tellan; Francesco Pugliese; Maria De Giusti; Corrado De Vito; Carolina Marzuillo; Paolo Villari; Lavinia Camilla Barone; Dara Giannini; Daniela Marotta; Mattia Marte; Elena Mazzalai; Irma Germani; Arianna Bellini; Andrea Bongiovanni; Marta Castellani; Ludovica D'Agostino; Andrea De Giorgi; Chiara De Marchi; Elisa Mazzeo; Shadi Orlandi; Matteo Piattoli; Eleonora Ricci; Leonardo Maria Siena; Alessandro Territo; Stefano Zanni Journal: J Clin Med Date: 2022-03-07 Impact factor: 4.241
Authors: Mariateresa Ceparano; Valentina Baccolini; Giuseppe Migliara; Claudia Isonne; Erika Renzi; Daniela Tufi; Corrado De Vito; Maria De Giusti; Maria Trancassini; Francesco Alessandri; Giancarlo Ceccarelli; Francesco Pugliese; Paolo Villari; Maria Angiulli; Stefania Battellito; Arianna Bellini; Andrea Bongiovanni; Lucilla Caivano; Marta Castellani; Monica Coletti; Alessia Cottarelli; Ludovica D'Agostino; Andrea De Giorgi; Chiara De Marchi; Irma Germani; Dara Giannini; Elisa Mazzeo; Shadi Orlandi; Matteo Piattoli; Eleonora Ricci; Leonardo Maria Siena; Alessandro Territo; Gianluca Vrenna; Stefano Zanni; Carolina Marzuillo Journal: Microorganisms Date: 2022-03-28