Literature DB >> 3130360

A transplantable cell line derived from spontaneous hepatocellular carcinoma of the hereditary hepatitis LEC rat.

R Masuda1, M C Yoshida, M Sasaki, K Dempo, M Mori.   

Abstract

A serially transplantable rat hepatocellular carcinoma (HCC) line was established. The primary spontaneous HCC which developed in a 506-day-old male hereditary hepatitis LEC rat was inoculated into young LEC rats. Only this HCC of 18 primary HCCs was successful in serial transplantation. The established cell line was histologically identical to the primary HCC showing a well-differentiated type with a trabecular structure of tumorous hepatocytes. The characteristic of albumin production was maintained. Chromosome analysis revealed rather widely dispersed polyploid chromosome numbers with a modal value at 96. Every metaphase contained two to five unusually large marker chromosomes.

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Year:  1988        PMID： 3130360      PMCID： PMC5917461          DOI： 10.1111/j.1349-7006.1988.tb01584.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  13 in total

1.  A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

Authors:  J Summers; J M Smolec; R Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Amplification of activated c-Ha-ras-1 in human melanoma.

Authors:  T Sekiya; M Fushimi; S Hirohashi; A Tokunaga
Journal:  Jpn J Cancer Res       Date:  1985-07

3.  Transplantation of woodchuck hepatocellular carcinoma in nude mice.

Authors:  K Kobayashi; K Fukuoka; F Matsushita; H Morimoto; Y Hinoue; H Honjo; N Tanaka; T Sugimoto; Y Kato; N Hattori
Journal:  Hepatology       Date:  1983 Sep-Oct       Impact factor: 17.425

4.  Establishment of a cell line from a woodchuck hepatocellular carcinoma.

Authors:  M Unoura; K Kobayashi; K Fukuoka; F Matsushita; H Morimoto; T Oshima; S Kaneko; N Hattori; S Murakami; H Yoshikawa
Journal:  Hepatology       Date:  1985 Nov-Dec       Impact factor: 17.425

5.  Transposition and amplification of oncogene-related sequences in human neuroblastomas.

Authors:  N E Kohl; N Kanda; R R Schreck; G Bruns; S A Latt; F Gilbert; F W Alt
Journal:  Cell       Date:  1983-12       Impact factor: 41.582

6.  Duck hepatitis B virus and liver diseases.

Authors:  M Omata; K Uchiumi; Y Ito; O Yokosuka; J Mori; K Terao; Y Wei-Fa; A P O'Connell; W T London; K Okuda
Journal:  Gastroenterology       Date:  1983-08       Impact factor: 22.682

7.  New mutation causing hereditary hepatitis in the laboratory rat.

Authors:  M C Yoshida; R Masuda; M Sasaki; N Takeichi; H Kobayashi; K Dempo; M Mori
Journal:  J Hered       Date:  1987 Nov-Dec       Impact factor: 2.645

8.  Varying degrees of amplification of the N-ras oncogene in the human breast cancer cell line MCF-7.

Authors:  K A Graham; C L Richardson; M D Minden; J M Trent; R N Buick
Journal:  Cancer Res       Date:  1985-05       Impact factor: 12.701

9.  Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA.

Authors:  Y Suguoka; T Kano; A Okuda; M Sakai; T Kitagawa; M Muramatsu
Journal:  Nucleic Acids Res       Date:  1985-09-11       Impact factor: 16.971

10.  Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene.

Authors:  R Masuda; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Lab Anim       Date:  1988-04       Impact factor: 2.471
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  3 in total

1.  Two-dimensional electrophoretic analysis of hepatitis-associated polypeptides in liver of LEC rats developing spontaneous hepatitis.

Authors:  P J Wirth; Y Fujimoto; H Takahashi; M Mori; M C Yoshida; T Sugimura; M Nagao
Journal:  Jpn J Cancer Res       Date:  1990-05

2.  High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis.

Authors:  R Masuda; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Jpn J Cancer Res       Date:  1988-07

3.  Gene expression of placental glutathione S-transferase in hereditary hepatitis and spontaneous hepatocarcinogenesis of LEC strain rats.

Authors:  R Masuda; M C Yoshida; M Sasaki
Journal:  Jpn J Cancer Res       Date:  1989-11
  3 in total

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