Majid Naderi1, Nader Cohan2, Sezaneh Haghpanah2, Ghasem Miri-Aliabad3, Iraj Shahramian4, Minoo Ahmadinejad5, Simin Sadeghi3, Akbar Dorgalaleh6, Hossein Ali Khazaei7, Mehran Karimi8. 1. Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. 2. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 3. Department of Pediatric, Zahedan University of Medical Sciences, Zahedan, Iran. 4. Pediatric Digestive and Hepatic Research Center, Zabol University of Medical Sciences, Zabol, Iran. 5. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. 6. Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. 7. Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. 8. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mkarimi820@gmail.com.
Abstract
OBJECTIVES: The ISTH bleeding assessment tool (ISTH-BAT) is developed for standardization of bleeding symptoms in bleeding disorders. The aim of this study is to apply this bleeding score for FXIII deficient patients and its relation to the frequency and severity of symptoms. METHODS: In this cross-sectional study, 63 patients with severe FXIII deficiency were evaluated for the assessment of bleeding score according to the standard ISTH-BAT questionnaire. All patients were registered at two major thrombosis and hemostasis centers in Iran affiliated to Zahedan University of medical sciences (50 patients) and Shiraz University of medical sciences (13 patients). RESULTS: Significant correlations between the bleeding score and number of symptoms (r = 0.668, P < 0.001) and with a number of severe symptoms (r = 0.938, P < 0.001) were detected. There was no significant relationship between the mean bleeding score and CNS bleeding (P = 0.390). CONCLUSION: The ISTH-BAT score is an acceptable bleeding assessment tool for standardization and evaluation of patients with FXIII deficiency.
OBJECTIVES: The ISTH bleeding assessment tool (ISTH-BAT) is developed for standardization of bleeding symptoms in bleeding disorders. The aim of this study is to apply this bleeding score for FXIII deficient patients and its relation to the frequency and severity of symptoms. METHODS: In this cross-sectional study, 63 patients with severe FXIII deficiency were evaluated for the assessment of bleeding score according to the standard ISTH-BAT questionnaire. All patients were registered at two major thrombosis and hemostasis centers in Iran affiliated to Zahedan University of medical sciences (50 patients) and Shiraz University of medical sciences (13 patients). RESULTS: Significant correlations between the bleeding score and number of symptoms (r = 0.668, P < 0.001) and with a number of severe symptoms (r = 0.938, P < 0.001) were detected. There was no significant relationship between the mean bleeding score and CNS bleeding (P = 0.390). CONCLUSION: The ISTH-BAT score is an acceptable bleeding assessment tool for standardization and evaluation of patients with FXIII deficiency.
Authors: Alexander C Schulick; Hunter B Moore; Carson B Walker; Hillary Yaffe; James J Pomposelli; Fareed Azam; Michael Wachs; Thomas Bak; Peter Kennealey; Kendra Conzen; Megan Adams; Thomas Pshak; Rashikh Choudhury; Michael P Chapman; Elizabeth A Pomfret; Trevor L Nydam Journal: Am J Surg Date: 2020-09-01 Impact factor: 2.565