Huachao Shen1, Zhengze Dai2, Mengmeng Wang3, Shiyuan Gu4, Wei Xu5, Gelin Xu6, Xinfeng Liu7. 1. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Neurology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 2. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Neurology, Nanjing Pukou Hospital, Nanjing, Jiangsu, China. 3. Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China. 4. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China; Department of Neurology, Yixing People's Hospital Affiliated to Jiangsu University, Yixing, Jiangsu, China. 5. Department of Neurology, Jingling Hospital, Southern Medical University, Nanjing, Jiangsu, China; Department of Neurology, Changsha Central Hospital, Changsha, Hunan, China. 6. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China. 7. Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: xfliu2@vip.163.com.
Abstract
BACKGROUND AND PURPOSE: In-stent restenosis (ISR) is unfavorable to the long-term efficacy of carotid angioplasty and stenting (CAS). Inflammation plays a critical role in the development of ISR. The aim of the study was to investigate whether neutrophil to albumin ratio (NAR) is a predictor of ISR in patients undergoing CAS. METHODS: We retrospectively recruited patients who underwent CAS. These patients were divided into restenosis group and nonrestenosis group. NAR was examined prior to the CAS procedure. Clinical and radiographic assessments were performed at 6 months and annually after the procedure. ISR was defined as greater than or equal to 50% stenosis in the treated lesion. Cox regression was used to identify predictors of ISR following CAS. RESULTS: During a mean follow-up period of 14.6 months, a total of 459 treated arteries (in 427 participants) were enrolled, among which 72 (15.7%) developed ISR. On multivariate analysis, baseline NAR greater than or equal to13.4, residual stenosis, lesion length, and baseline glucose level were associated with ISR (hazard ratio 1.94[95% confidence interval (CI), 1.08-3.49], 1.09[95% CI, 1.07-1.12], 1.04[95% CI, 1.01-1.06], and 1.01[95% CI, 1.00-1.02], respectively). CONCLUSION: Elevated preprocedural NAR may be a predictor of ISR in patients undergoing CAS.
BACKGROUND AND PURPOSE: In-stent restenosis (ISR) is unfavorable to the long-term efficacy of carotid angioplasty and stenting (CAS). Inflammation plays a critical role in the development of ISR. The aim of the study was to investigate whether neutrophil to albumin ratio (NAR) is a predictor of ISR in patients undergoing CAS. METHODS: We retrospectively recruited patients who underwent CAS. These patients were divided into restenosis group and nonrestenosis group. NAR was examined prior to the CAS procedure. Clinical and radiographic assessments were performed at 6 months and annually after the procedure. ISR was defined as greater than or equal to 50% stenosis in the treated lesion. Cox regression was used to identify predictors of ISR following CAS. RESULTS: During a mean follow-up period of 14.6 months, a total of 459 treated arteries (in 427 participants) were enrolled, among which 72 (15.7%) developed ISR. On multivariate analysis, baseline NAR greater than or equal to13.4, residual stenosis, lesion length, and baseline glucose level were associated with ISR (hazard ratio 1.94[95% confidence interval (CI), 1.08-3.49], 1.09[95% CI, 1.07-1.12], 1.04[95% CI, 1.01-1.06], and 1.01[95% CI, 1.00-1.02], respectively). CONCLUSION: Elevated preprocedural NAR may be a predictor of ISR in patients undergoing CAS.