| Literature DB >> 31303401 |
Yoko Soroida1, Takuma Nakatsuka2, Masaya Sato3, Hayato Nakagawa4, Mariko Tanaka5, Naoko Yamauchi5, Taijiro Wake2, Ryo Nakagomi2, Mizuki Nishibatake Kinoshita2, Tatsuya Minami2, Koji Uchino2, Kenichiro Enooku2, Yoshinari Asaoka2, Yasuo Tanaka2, Momoe Endo1, Ayaka Nakamura1, Tamaki Kobayashi1, Makiko Kurihara1, Hiromi Hikita1, Mamiko Sato1, Hiroaki Gotoh1, Tomomi Iwai1, Masashi Fukayama5, Hitoshi Ikeda1, Ryosuke Tateishi2, Yutaka Yatomi1, Kazuhiko Koike2.
Abstract
The hepatic vein (HV) waveform by Doppler ultrasound reflects the severity of liver fibrosis. We conducted a proof-of-concept study of a new method for quantifying the HV waveform. We calculated the coefficient of variation (CV) of the HV flow velocity and created a new index "q-HV" (quantified HV) and analyzed its performance for predicting histologic liver fibrosis in 114 patients with chronic liver disease. The CV of the HV flow velocity was well associated with flattening of the waveform and the q-HV significantly increased with the progression of liver fibrosis. The areas under the curve for the prediction of fibrosis stage were 0.732 for F2, 0.772 for F3 and 0.805 for F4. Combined q-HV and FIB-4 index (widely used liver fibrosis score) increased the diagnostic accuracy for liver fibrosis. The q-HV showed good accuracy for predicting liver fibrosis; thus, q-HV is feasible and acceptable as a non-invasive tool for predicting liver fibrosis.Entities:
Keywords: Doppler; Hepatic vein waveform; Liver fibrosis; Ultrasonography
Mesh：
Year: 2019 PMID： 31303401 DOI： 10.1016/j.ultrasmedbio.2019.05.028
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998