| Literature DB >> 31303272 |
Tadashi Kegasawa1, Tomohide Tatsumi1, Teppei Yoshioka1, Takahiro Suda1, Kenji Ikezawa1, Tasuku Nakabori1, Ryoko Yamada1, Takahiro Kodama1, Minoru Shigekawa1, Hayato Hikita1, Ryotaro Sakamori1, Tetsuo Takehara2.
Abstract
The immune system plays important roles in pancreatic cancer. MHC class I-chain-related proteins A and B (MICA/B) and UL16-binding proteins (ULBPs) are known natural killer group 2D (NKG2D) ligands. Soluble NKG2D ligands can inhibit the activation of Natural killer (NK) cells. In pancreatic cancer, soluble ULBPs are relatively unstudied in contrast to soluble MICA/B. We examined the significance of soluble ULBPs, especially ULBP2, in pancreatic cancer. Soluble ULBP2 but neither soluble ULBP1 nor soluble ULBP3, was etected in the supernatants of pancreatic cancer cells. Soluble ULBP2 derived from pancreatic cancer cells could reduce the cytotoxicity of NK cells. Multivariate analysis demonstrated that serum soluble ULBP2 was a significant independent factor associated with poor overall survival (OS) in all pancreatic cancer patients, specifically in stage IV patients. In conclusion, pancreatic cancer-derived soluble ULBP2 might affect the prognosis in pancreatic cancer.Entities:
Keywords: Cytotoxicity; NK cells; NKG2D; Pancreatic cancer; Prognosis; Soluble ULBP2
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Year: 2019 PMID： 31303272 DOI： 10.1016/j.bbrc.2019.07.020
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575