| Literature DB >> 31303058 |
Van-Kieu Nguyen1, Jirapast Sichaem2, Huu-Hung Nguyen3, Xuan Hieu Nguyen4, Thi-Thu-Loi Huynh4, Thi-Phuong Nguyen3, Nakorn Niamnont5, Dinh-Hung Mac6, Duc-Dung Pham4, Warinthorn Chavasiri1, Kim-Phi-Phung Nguyen7, Thuc-Huy Duong8,9.
Abstract
A series of usnic acid benzylidene derivatives (groups I-V) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0 ± 3.6, 5.6 ± 0.4, 8.8 ± 1.0, 4.5 ± 0.1 and 8.4 ± 0.4 μM, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.Entities:
Keywords: Usnic acid; aldol condensation; benzylidene derivative; cytotoxicity
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Year: 2019 PMID： 31303058 DOI： 10.1080/14786419.2019.1639176
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861