Literature DB >> 3130250

Inducibility of rat brain drug-metabolizing enzymes.

J F Ghersi-Egea1, B Walther, R Perrin, A Minn, G Siest.   

Abstract

Cytochrome P450 from rat brain mitochondrial and microsomal fractions was found to be inducible by 3-methylcholanthrene, both in quantity of enzyme and in activity towards 7-ethoxyresorufin, which is a model substrate for the cytochrome P450 isoform specifically induced by 3-methylcholanthrene. Conversely, a phenobarbital treatment resulted in an induction of the microsomal cytochrome P450 only. On the other hand, the microsomal 1-naphthol-UDP-glucuronosyl transferase and epoxide hydrolase seemed to be non-inducible by 3-methylcholanthrene or by phenobarbital. The toxicological implications of these data are discussed.

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Year:  1987        PMID： 3130250     DOI： 10.1007/BF03189910

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  12 in total

1.  Characterization of cytochrome P-450-dependent aminopyrine N-demethylase in rat brain: comparison with hepatic aminopyrine N-demethylation.

Authors:  M P Marietta; E S Vesell; R D Hartman; J Weisz; B H Dvorchik
Journal:  J Pharmacol Exp Ther       Date:  1979-02       Impact factor: 4.030

2.  Quantitative measurement of cerebral cytochrome P-450 by second derivative spectrophotometry.

Authors:  J F Ghersi-Egea; B Walther; A Minn; G Siest
Journal:  J Neurosci Methods       Date:  1987-07       Impact factor: 2.390

3.  Ethoxyresorufin O-deethylase activity in rat brain subcellular fractions.

Authors:  B Walther; J F Ghersi-Egea; Z Jayyosi; A Minn; G Siest
Journal:  Neurosci Lett       Date:  1987-04-23       Impact factor: 3.046

4.  Cytochrome P-450 and NADPH cytochrome c reductase in rat brain: formation of catechols and reactive catechol metabolites.

Authors:  H A Sasame; M M Ames; S D Nelson
Journal:  Biochem Biophys Res Commun       Date:  1977-10-10       Impact factor: 3.575

5.  Continous fluorometric assay of epoxide hydrase activity.

Authors:  P M Dansette; G C DuBois; D M Jerina
Journal:  Anal Biochem       Date:  1979-09-01       Impact factor: 3.365

6.  Effects of phenobarbital and sodium salicylate on cytochrome P-450 mixed function oxygenase and glutathione S-transferase activities in rat brain.

Authors:  P Chand; J Clausen
Journal:  Chem Biol Interact       Date:  1982-07-01       Impact factor: 5.192

7.  Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

Authors:  M D Burke; R T Mayer
Journal:  Drug Metab Dispos       Date:  1974 Nov-Dec       Impact factor: 3.922

8.  The activity of 1-naphthol-UDP-glucuronosyltransferase in the brain.

Authors:  J F Ghersi-Egea; B Walther; D Decolin; A Minn; G Siest
Journal:  Neuropharmacology       Date:  1987-04       Impact factor: 5.250

9.  Subcellular distribution of cytochrome P-450 in the brain.

Authors:  B Walther; J F Ghersi-Egea; A Minn; G Siest
Journal:  Brain Res       Date:  1986-06-11       Impact factor: 3.252

10.  6. Steroid metabolism in neuroendocrine structures. Specific and nonspecific components in the oxidative metabolism of estradiol by the male rat brain in vitro.

Authors:  J Fishman; B Norton
Journal:  J Steroid Biochem       Date:  1983-07       Impact factor: 4.292
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  8 in total

1.  Pharmacological and toxicological significance of brain cytochromes P450.

Authors:  V Ravindranath
Journal:  Neurotox Res       Date:  2001-08       Impact factor: 3.911

Review 2.  Drug-metabolizing cytochrome P450s in the brain.

Authors:  Sharon L Miksys; Rachel F Tyndale
Journal:  J Psychiatry Neurosci       Date:  2002-11       Impact factor: 6.186

3.  NADPH:cytochrome P-450(c) reductase: biochemical characterization in rat brain and cultured neurons and evolution of activity during development.

Authors:  J F Ghersi-Egea; A Minn; J L Daval; Z Jayyosi; V Arnould; H Souhaili-El Amri; G Siest
Journal:  Neurochem Res       Date:  1989-09       Impact factor: 3.996

4.  Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains.

Authors:  Chaitali Ghosh; Mohammed Hossain; Vikram Puvenna; Jorge Martinez-Gonzalez; Andreas Alexopolous; Damir Janigro; Nicola Marchi
Journal:  Epilepsia       Date:  2013-07-19       Impact factor: 5.864

5.  Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow.

Authors:  Chaitali Ghosh; Jorge Gonzalez-Martinez; Mohammed Hossain; Luca Cucullo; Vincent Fazio; Damir Janigro; Nicola Marchi
Journal:  Epilepsia       Date:  2010-01-13       Impact factor: 5.864

6.  Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients.

Authors:  E A Lien; K Wester; P E Lønning; E Solheim; P M Ueland
Journal:  Br J Cancer       Date:  1991-04       Impact factor: 7.640

Review 7.  The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.

Authors:  Mohamed Ouzzine; Sandrine Gulberti; Nick Ramalanjaona; Jacques Magdalou; Sylvie Fournel-Gigleux
Journal:  Front Cell Neurosci       Date:  2014-10-28       Impact factor: 5.505

8.  Developmental differences in the expression of ABC transporters at rat brain barrier interfaces following chronic exposure to diallyl sulfide.

Authors:  Liam M Koehn; Katarzyna M Dziegielewska; Kjeld Møllgård; Elodie Saudrais; Nathalie Strazielle; Jean-Francois Ghersi-Egea; Norman R Saunders; Mark D Habgood
Journal:  Sci Rep       Date:  2019-04-12       Impact factor: 4.379
  8 in total

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