Wanqiu Yang1, Guangya Zhang2, Qiufang Jia2, Zheng-Kang Qian2, Guangzhong Yin2, Xiaomin Zhu2, Omar I Alnatour3, Tammy H Trinh3, Hanjing Emily Wu3, XiaoE Lang4, Xiangdong Du5, Xiangyang Zhang6. 1. The Mental Health Center, Yunnan University, Kunming, China. 2. Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 286 Guangji Road, Suzhou, Jiangsu Province, China. 3. Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA. 4. Department of Psychiatry, The First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi Province, China. 5. Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 286 Guangji Road, Suzhou, Jiangsu Province, China. Electronic address: xiangdong-du@163.com. 6. CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address: zhangxy@psych.ac.cn.
Abstract
BACKGROUND: Anxiety is a common comorbidity in major depressive disorder (MDD) that has been studied extensively in the past. However, few studies have explored anxiety in drug naïve (FEDN) patients with MDD and those presenting with a first episode. The objective of this current study was to examine the prevalence and risk factors of anxiety in FEDN patients with MDD in order to understand the relationship between MDD and anxiety in the acute early phase and provide important implications for therapeutic interventions. METHODS: A total of 1718 FEDN patients with MDD were recruited in this cross-sectional study. Their anthropometric and clinical data, including suicide attempt and psychotic symptom, were collected. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were used to evaluate depression and anxiety for all the patients in this study. RESULTS: Overall, we found that the prevalence of anxiety in FEDN MDD patients was 80.3%. Correlation analysis showed that anxiety was associated with suicide attempt and psychotic symptom in FEDN patients with MDD. The rate of suicide attempt and psychosis in above patients with anxiety was 24.3% and 12.3%, respectively. Furthermore, stepwise regression analysis showed that suicide attempt and psychotic symptom were significant predictors for anxiety in FEDN patients with MDD. CONCLUSIONS: Our study showed that the prevalence of comorbid anxiety in FEDN patients with MDD is very high. We also found that two clinical variables, suicide attempt and psychosis, are risk factors for comorbid anxiety in FEDN patients with MDD.
BACKGROUND:Anxiety is a common comorbidity in major depressive disorder (MDD) that has been studied extensively in the past. However, few studies have explored anxiety in drug naïve (FEDN) patients with MDD and those presenting with a first episode. The objective of this current study was to examine the prevalence and risk factors of anxiety in FEDN patients with MDD in order to understand the relationship between MDD and anxiety in the acute early phase and provide important implications for therapeutic interventions. METHODS: A total of 1718 FEDN patients with MDD were recruited in this cross-sectional study. Their anthropometric and clinical data, including suicide attempt and psychotic symptom, were collected. The Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) were used to evaluate depression and anxiety for all the patients in this study. RESULTS: Overall, we found that the prevalence of anxiety in FEDN MDDpatients was 80.3%. Correlation analysis showed that anxiety was associated with suicide attempt and psychotic symptom in FEDN patients with MDD. The rate of suicide attempt and psychosis in above patients with anxiety was 24.3% and 12.3%, respectively. Furthermore, stepwise regression analysis showed that suicide attempt and psychotic symptom were significant predictors for anxiety in FEDN patients with MDD. CONCLUSIONS: Our study showed that the prevalence of comorbid anxiety in FEDN patients with MDD is very high. We also found that two clinical variables, suicide attempt and psychosis, are risk factors for comorbid anxiety in FEDN patients with MDD.
Authors: Joana Vanessa Reis; Rita Vieira; Carlos Portugal-Nunes; Ana Coelho; Ricardo Magalhães; Pedro Moreira; Sónia Ferreira; Maria Picó-Pérez; Nuno Sousa; Nuno Dias; João M Bessa Journal: Front Psychiatry Date: 2022-03-21 Impact factor: 4.157