W Wirth1, S Maschek2, F W Roemer3, L Sharma4, G N Duda5, F Eckstein2. 1. Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany. Electronic address: wolfgang.wirth@pmu.ac.at. 2. Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany. 3. Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany; Department of Radiology, Boston University School of Medicine, Boston, MA, USA. 4. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 5. Julius Wolff Institute and Berlin-Brandenburg Center for Regenerative Therapies, Charite - Universitätsmedizin, Berlin, Germany.
Abstract
OBJECTIVE: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. METHODS: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. RESULTS: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [-0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. CONCLUSIONS: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. CLINICALTRIALS. GOV IDENTIFICATION: NCT00080171.
OBJECTIVE: To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. METHODS: 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. RESULTS: Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m2), 21/22/13/4 displayed contralateral JSN 0/1/2/3, respectively. The longitudinal increase in the deep layer cartilage T2 between Y1 and Y4 was significantly greater (P = 0.03; Cohen's D 0.50) in the 39 KLG0 case knees with contralateral JSN (1.2 ms; 95% confidence interval [CI] [0.4, 2.0]) than in matched KLG0 reference knees (0.1 ms; 95% CI [-0.5, 0.7]). No significant differences were identified in superficial T2 change. T2 at Y1 was significantly greater in case than in reference knees, particularly in the superficial layer of the medial compartment. CONCLUSIONS: Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. CLINICALTRIALS. GOV IDENTIFICATION: NCT00080171.
Authors: Hans Liebl; Gabby Joseph; Michael C Nevitt; Nathan Singh; Ursula Heilmeier; Karupppasamy Subburaj; Pia M Jungmann; Charles E McCulloch; John A Lynch; Nancy E Lane; Thomas M Link Journal: Ann Rheum Dis Date: 2014-03-10 Impact factor: 19.103
Authors: E Lammentausta; P Kiviranta; M J Nissi; M S Laasanen; I Kiviranta; M T Nieminen; J S Jurvelin Journal: J Orthop Res Date: 2006-03 Impact factor: 3.494
Authors: Pia M Jungmann; Mareen S Kraus; Lorenzo Nardo; Hans Liebl; Hamza Alizai; Gabby B Joseph; Felix Liu; John Lynch; Chuck E McCulloch; Michael C Nevitt; Thomas M Link Journal: J Magn Reson Imaging Date: 2013-09-13 Impact factor: 4.813
Authors: Kevin A Thomas; Dominik Krzemiński; Łukasz Kidziński; Rohan Paul; Elka B Rubin; Eni Halilaj; Marianne S Black; Akshay Chaudhari; Garry E Gold; Scott L Delp Journal: Cartilage Date: 2021-09-08 Impact factor: 3.117
Authors: Anna Wisser; Andreas Lapper; Frank Roemer; David Fuerst; Susanne Maschek; Wolfgang Wirth; Georg N Duda; Felix Eckstein Journal: Cartilage Date: 2020-12-24 Impact factor: 3.117
Authors: Frank W Roemer; Felix Eckstein; Georg Duda; Ali Guermazi; Susanne Maschek; Leena Sharma; Wolfgang Wirth Journal: Cartilage Date: 2020-06-12 Impact factor: 3.117