Jessica Trung1, Alexandru Hanganu2, Stevan Jobert1, Clotilde Degroot3, Beatriz Mejia-Constain1, Mekale Kibreab4, Marie-Andrée Bruneau1, Anne-Louise Lafontaine5, Antonio Strafella6, Oury Monchi7. 1. CIUSSS Centre-Sud-de-l'Île-de-Montréal, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. 2. CIUSSS Centre-Sud-de-l'Île-de-Montréal, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada; Department of Psychology, University of Montreal, Montreal, QC, Canada. 3. CIUSSS Centre-Sud-de-l'Île-de-Montréal, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; McGill University, Montreal, QC, Canada. 4. Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada. 5. Movement Disorders Unit, McGill University Health Center, Montreal, QC, Canada. 6. Department of Medicine, Division of Neurology, University of Toronto, ON, Canada. 7. CIUSSS Centre-Sud-de-l'Île-de-Montréal, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada; Department of Clinical Neurosciences and Department of Radiology, University of Calgary, Calgary, AB, Canada; Hotchkiss Brain Institute, Cumming School of Medicine, Calgary, AB, Canada; McGill University, Montreal, QC, Canada. Electronic address: oury.monchi@ucalgary.ca.
Abstract
INTRODUCTION: Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulation studies over the left DLPFC showed short-term improvement in cognitive performance and focused on specific task. METHODS:28 patients with idiopathic Parkinson's disease and mild cognitive impairment receivedintermittent "theta burst" stimulation (iTBS) (active, N = 14; or sham, N = 14) over the left DLPFC, twice a day for three days with 1-2 days in between. Detailed neuropsychological assessment of five cognitive domains was performed before iTBS and on days 1, 10, and 30 after the last iTBS session. Composite Z-scores were calculated for each domain and for overall cognition. RESULTS: Our results showed an increase in overall cognition up to one month in both groups but this effect was only significant in the active group. Improvements were seen in the attention domain for both groups and in the visuospatial domain in the active group only. No significant differences were found between the groups. CONCLUSION: These preliminary findings suggest that active iTBS might improve overall cognitive performance in patients with Parkinson's disease with mild cognitive impairment and that this effect can last up to one month. This cognitive improvement, is likely mediated by improvement on visuospatial abilities. Further studies are needed to explore the potential of iTBS as a therapeutical tool to slow cognitive decline in patients with Parkinson's disease.
RCT Entities:
INTRODUCTION:Cognitive impairment can occur in the early phase of Parkinson's disease and increases the risk of developing dementia. Cognitive deficits were shown to be associated with functional alterations in the dorsolateral prefrontal cortex (DLPFC) and caudate nucleus. Two previous transcranial magnetic stimulation studies over the left DLPFC showed short-term improvement in cognitive performance and focused on specific task. METHODS: 28 patients with idiopathic Parkinson's disease and mild cognitive impairment received intermittent "theta burst" stimulation (iTBS) (active, N = 14; or sham, N = 14) over the left DLPFC, twice a day for three days with 1-2 days in between. Detailed neuropsychological assessment of five cognitive domains was performed before iTBS and on days 1, 10, and 30 after the last iTBS session. Composite Z-scores were calculated for each domain and for overall cognition. RESULTS: Our results showed an increase in overall cognition up to one month in both groups but this effect was only significant in the active group. Improvements were seen in the attention domain for both groups and in the visuospatial domain in the active group only. No significant differences were found between the groups. CONCLUSION: These preliminary findings suggest that active iTBS might improve overall cognitive performance in patients with Parkinson's disease with mild cognitive impairment and that this effect can last up to one month. This cognitive improvement, is likely mediated by improvement on visuospatial abilities. Further studies are needed to explore the potential of iTBS as a therapeutical tool to slow cognitive decline in patients with Parkinson's disease.
Authors: Qiang Zhang; Georgina M Aldridge; Nandakumar S Narayanan; Steven W Anderson; Ergun Y Uc Journal: Neurotherapeutics Date: 2020-11-17 Impact factor: 6.088
Authors: Ziv Gan-Or; Trisha Rao; Etienne Leveille; Clotilde Degroot; Sylvain Chouinard; Francesca Cicchetti; Alain Dagher; Samir Das; Alex Desautels; Janelle Drouin-Ouellet; Thomas Durcan; Jean-François Gagnon; Angela Genge; Jason Karamchandani; Anne-Louise Lafontaine; Sonia Lai Wing Sun; Mélanie Langlois; Martin Levesque; Calvin Melmed; Michel Panisset; Martin Parent; Jean-Baptiste Poline; Ronald B Postuma; Emmanuelle Pourcher; Guy A Rouleau; Madeleine Sharp; Oury Monchi; Nicolas Dupré; Edward A Fon Journal: J Parkinsons Dis Date: 2020 Impact factor: 5.568
Authors: J Nicole Bentley; Zachary T Irwin; Sarah D Black; Megan L Roach; Ryan J Vaden; Christopher L Gonzalez; Anas U Khan; Galal A El-Sayed; Robert T Knight; Barton L Guthrie; Harrison C Walker Journal: Front Neurosci Date: 2020-01-31 Impact factor: 4.677