| Literature DB >> 31300127 |
José Weverton Almeida Bezerra1, Adrielle Rodrigues Costa2, Maria Audilene de Freitas3, Felicidade Caroline Rodrigues4, Mikael Amaro de Souza2, Ana Raquel Pereira da Silva5, Antonia Thassya Lucas Dos Santos6, Karina Vieiralves Linhares5, Henrique Douglas Melo Coutinho7, Jailson Renato de Lima Silva7, Maria Flaviana Bezerra Morais-Braga6.
Abstract
The oil presented the α-Terpinene as the major compound with 54.09% presence. Antibacterial activity demonstrated significant MIC against Staphylococcus aureus (256 μg/mL) and moderate against Pseudomonas aeruginosa (512 μg/mL). The modulating effect of antibiotics was significant against P. aeruginosa potentiating the effect of all the antibiotics tested. The IC50 observed for CT LM 23 was clinically relevant (19.3 μg/mL), similar to that obtained for CA INCQS 40006 (25.2 μg/mL). The combined effect with fluconazole also showed significant results, 0.1 and 22.7 μg/mL, for CT LM 23 and CA INCQS 40006, respectively. For CA LM 77 the IC50 was 101.9 μg/mL and for CT INCQS 40042 a value of 53.3 μg/mL. Regarding the modulation, both were considered of clinical relevance, 3.3 and 6.4 μg/mL. OEDA has low antioxidant activity (>1024 μg/mL). Therefore, the popular use against infections was corroborated by this work.Entities:
Keywords: Chenopodium ambrosioides; DPPH; Natural product; Terpenes
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Year: 2019 PMID： 31300127 DOI： 10.1016/j.cimid.2019.04.010
Source DB: PubMed Journal: Comp Immunol Microbiol Infect Dis ISSN： 0147-9571 Impact factor: 2.268