Effect of Mechanical Tension on the circRNA Expression Profile of Human Skin Tissue.

Skin soft tissue dilatation has emerged as one of the most prominent methods to skin defects spanning large areas. However, effective expansion of additional skin tissue is still the most challenging problem. This study aimed to understand the potential role of circular RNAs (circRNAs) in gene regulation during skin regeneration via analysis of the circRNA expression profile of skin tissue during skin regeneration under mechanical tension. In total, 1039 circRNAs were identified, of which 126 were newly identified. Furthermore, 48 circRNAs were differentially expressed between the experimental and control groups, which were annotated with gene ontology and kyoto encyclopedia of genes and genomes functions, and the regulatory network of microRNA (miRNA)-circRNA was established. The present results provide a theoretical basis for future studies on the mechanism underlying skin regeneration.