Stephen J Walker1, Andre Plair2, Kshipra Hemal3, Carl D Langefeld4, Catherine Matthews2, Gopal Badlani2, Joao Zambon2, Heather Heath5, Robert J Evans2. 1. Department of Urology/Female Pelvic Health, Wake Forest Baptist Medical Center, Winston-Salem, NC; Wake Forest Institute for Regenerative Medicinske Forest Baptist Medical Center, Winston-Salem, NC. Electronic address: swalker@wakehealth.edu. 2. Department of Urology/Female Pelvic Health, Wake Forest Baptist Medical Center, Winston-Salem, NC. 3. Wake Forest University School of Medicine, Winston-Salem, NC. 4. Department of Biostatistics and Data Science, Wake Forest Baptist Medical Center, Winston-Salem, NC. 5. Wake Forest Institute for Regenerative Medicinske Forest Baptist Medical Center, Winston-Salem, NC.
Abstract
OBJECTIVE: To assess the impact of multiple (2 or more) bladder hydrodistentions (HODs) on anesthetic bladder capacity (BC) in a large cohort of interstitial cystitis/bladder pain syndrome (IC/BPS) patients. Urinary HOD under anesthesia is a third line therapeutic approach used to treat patients with IC/BPS. There is some concern that performing multiple therapeutic HODs may be contraindicated due to the potential for contributing to a diminished BC over time. MATERIALS AND METHODS: This is a retrospective chart review of IC/BPS patients from a single institution who had undergone 2 or more bladder HOD procedures. Patient demographic and clinical data, including BC under anesthesia, were retrieved from patient charts for analysis. Least squares regression slopes of BC under anesthesia were calculated and used to estimate within-patient BC changes over time. RESULTS: Data from 168 patients (637 HOD procedures) were included for analysis. The average change in BC, 0.52 ± 8.33 mL/mo, was not significantly different from 0 (P= .42). Linear regression analyses did not identify any significant correlation between BC over time with: (1) age, (2) number of HODs, (3) frequency of HODs, (4) average BC, (5) length of time with an IC/BPS diagnosis, or (6) length of time during which the patient's BC was evaluated. Moreover, there was no difference in BC change over time in patients with and without Hunner's lesion (P = .86). CONCLUSION: Multiple therapeutic HODs, over several years, do not result in a significant change in BC in IC/BPS patients.
OBJECTIVE: To assess the impact of multiple (2 or more) bladder hydrodistentions (HODs) on anesthetic bladder capacity (BC) in a large cohort of interstitial cystitis/bladder pain syndrome (IC/BPS) patients. Urinary HOD under anesthesia is a third line therapeutic approach used to treat patients with IC/BPS. There is some concern that performing multiple therapeutic HODs may be contraindicated due to the potential for contributing to a diminished BC over time. MATERIALS AND METHODS: This is a retrospective chart review of IC/BPSpatients from a single institution who had undergone 2 or more bladder HOD procedures. Patient demographic and clinical data, including BC under anesthesia, were retrieved from patient charts for analysis. Least squares regression slopes of BC under anesthesia were calculated and used to estimate within-patientBC changes over time. RESULTS: Data from 168 patients (637 HOD procedures) were included for analysis. The average change in BC, 0.52 ± 8.33 mL/mo, was not significantly different from 0 (P= .42). Linear regression analyses did not identify any significant correlation between BC over time with: (1) age, (2) number of HODs, (3) frequency of HODs, (4) average BC, (5) length of time with an IC/BPS diagnosis, or (6) length of time during which the patient's BC was evaluated. Moreover, there was no difference in BC change over time in patients with and without Hunner's lesion (P = .86). CONCLUSION: Multiple therapeutic HODs, over several years, do not result in a significant change in BC in IC/BPSpatients.
Authors: Deborah R Erickson; Allen R Kunselman; Christina M Bentley; Kenneth M Peters; Eric S Rovner; Laurence M Demers; Marcia A Wheeler; Susan K Keay Journal: J Urol Date: 2007-02 Impact factor: 7.450
Authors: Marc Colaco; David S Koslov; Tristan Keys; Robert J Evans; Gopal H Badlani; Karl-Erik Andersson; Stephen J Walker Journal: J Urol Date: 2014-05-17 Impact factor: 7.450
Authors: Peter S Kirk; Yahir Santiago-Lastra; Yongmei Qin; John T Stoffel; James Q Clemens; Anne P Cameron Journal: Neurourol Urodyn Date: 2018-03-22 Impact factor: 2.696
Authors: Stephen J Walker; João Zambon; Karl-Erik Andersson; Carl D Langefeld; Catherine A Matthews; Gopal Badlani; Heather Bowman; Robert J Evans Journal: J Urol Date: 2017-02-12 Impact factor: 7.450
Authors: Andre Plair; Robert J Evans; Carl D Langefeld; Catherine A Matthews; Gopal Badlani; Stephen J Walker Journal: Urology Date: 2021-07-22 Impact factor: 2.649