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Literature DB >> 31299172

Development and Cell Biology of the Blood-Brain Barrier.

Urs H Langen¹, Swathi Ayloo¹, Chenghua Gu¹.

Abstract

The vertebrate vasculature displays high organotypic specialization, with the structure and function of blood vessels catering to the specific needs of each tissue. A unique feature of the central nervous system (CNS) vasculature is the blood-brain barrier (BBB). The BBB regulates substance influx and efflux to maintain a homeostatic environment for proper brain function. Here, we review the development and cell biology of the BBB, focusing on the cellular and molecular regulation of barrier formation and the maintenance of the BBB through adulthood. We summarize unique features of CNS endothelial cells and highlight recent progress in and general principles of barrier regulation. Finally, we illustrate why a mechanistic understanding of the development and maintenance of the BBB could provide novel therapeutic opportunities for CNS drug delivery.

Entities: Chemical

Keywords: astrocytes; blood-brain barrier; central nervous system; endothelial cells; neurovascular unit; pericytes

Mesh：

Year: 2019 PMID： 31299172 PMCID： PMC8934576 DOI： 10.1146/annurev-cellbio-100617-062608

Source DB: PubMed Journal: Annu Rev Cell Dev Biol ISSN： 1081-0706 Impact factor: 13.827

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