Literature DB >> 3129825

Preliminary characterization of a toxin isolated from the cyanobacterium Nodularia spumigena.

J E Eriksson1, J A Meriluoto, H P Kujari, K Osterlund, K Fagerlund, L Hällbom.   

Abstract

A peptide toxin was isolated from the cyanobacterium Nodularia spumigena by high performance liquid chromatography (HPLC). The i.p. LD50 of the toxin was 50 micrograms/kg mouse with death within 1-3 hr. The major effects of the toxin were seen in the liver in the form of extensive haemorrhages. Amino acid analysis showed the presence of equimolar amounts of glutamic acid, beta-methyl-aspartic acid, and arginine. The toxicological and some of the chemical properties of the isolated toxin were similar to those reported for hepatotoxins isolated from the cyanobacterium Microcystis aeruginosa.

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Year:  1988        PMID： 3129825     DOI： 10.1016/0041-0101(88)90168-7

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  8 in total

1.  Occurrence of the hepatotoxic cyanobacterium Nodularia spumigena in the Baltic Sea and structure of the toxin.

Authors:  K Sivonen; K Kononen; W W Carmichael; A M Dahlem; K L Rinehart; J Kiviranta; S I Niemela
Journal:  Appl Environ Microbiol       Date:  1989-08       Impact factor: 4.792

Review 2.  Metabolites produced by cyanobacteria belonging to several species of the family Nostocaceae.

Authors:  T Rezanka; V M Dembitsky
Journal:  Folia Microbiol (Praha)       Date:  2006       Impact factor: 2.099

Review 3.  On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin.

Authors:  Leanne Pearson; Troco Mihali; Michelle Moffitt; Ralf Kellmann; Brett Neilan
Journal:  Mar Drugs       Date:  2010-05-10       Impact factor: 5.118

4.  Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand.

Authors:  W W Carmichael; J T Eschedor; G M Patterson; R E Moore
Journal:  Appl Environ Microbiol       Date:  1988-09       Impact factor: 4.792

5.  First report of a toxic Nodularia spumigena (Nostocales/ Cyanobacteria) bloom in sub-tropical Australia. I. Phycological and public health investigations.

Authors:  Glenn B McGregor; Ian Stewart; Barbara C Sendall; Ross Sadler; Karen Reardon; Steven Carter; Dan Wruck; Wasa Wickramasinghe
Journal:  Int J Environ Res Public Health       Date:  2012-07-05       Impact factor: 3.390

Review 6.  Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.

Authors:  Rune Kleppe; Lars Herfindal; Stein Ove Døskeland
Journal:  Mar Drugs       Date:  2015-10-22       Impact factor: 5.118

7.  Draft Genome Assembly of the Bloom-Forming Cyanobacterium Nodularia spumigena Strain CENA596 in Shrimp Production Ponds.

Authors:  Rafael Vicentini Popin; Janaina Rigonato; Vinicius Augusto Carvalho Abreu; Ana Paula Dini Andreote; Savênia Bonoto Silveira; Clarisse Odebrecht; Marli Fatima Fiore
Journal:  Genome Announc       Date:  2016-06-09

8.  Rapid and Highly Sensitive Non-Competitive Immunoassay for Specific Detection of Nodularin.

Authors:  Sultana Akter; Markus Vehniäinen; Harri T Kankaanpää; Urpo Lamminmäki
Journal:  Microorganisms       Date:  2017-09-12
  8 in total

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