Literature DB >> 31298196

In Vitro Gametogenesis and the Creation of 'Designer Babies'.

Seppe Segers, Guido Pennings, Wybo Dondorp, Guido DE Wert, Heidi Mertes.   

Abstract

Research into the development of stem cell-derived (SCD) gametes in humans, otherwise known as in vitro gametogenesis (IVG), is largely motivated by reproductive aims. Especially, the goal of establishing genetic parenthood by means of SCD-gametes is considered an important aim. However, like other applications in the field of assisted reproduction, this technology evokes worries about the possibility of creating so-called 'designer babies.' In this paper, we investigate various ways in which SCD-gametes could be used to create such preference-matched offspring, and what this would mean for the acceptability of IVG, if it is premised that it is morally problematic to 'design' offspring. We argue that IVG might facilitate the creation of preference-matched offspring, but conclude that this should not undermine the moral acceptability of IVG altogether-even if one concedes the premise that creating 'designer babies' is morally problematic. In the light of this, we also point at a possible inconsistency for a position that condemns the creation of 'designer offspring,' while accepting the various endeavors to have genetically related offspring.

Entities:  

Keywords:  artificial gametes; assisted reproduction; designer babies; gamete derivation; gene editing; genetic parenthood; in vitro gametogenesis; stem cells

Mesh:

Year:  2019        PMID: 31298196     DOI: 10.1017/S0963180119000422

Source DB:  PubMed          Journal:  Camb Q Healthc Ethics        ISSN: 0963-1801            Impact factor:   1.284


  4 in total

Review 1.  Stem cell preservation for regenerative therapies: ethical and governance considerations for the health care sector.

Authors:  Zubin Master; Aidan P Crowley; Cambray Smith; Dennis Wigle; Andre Terzic; Richard R Sharp
Journal:  NPJ Regen Med       Date:  2020-12-01

2.  Enthusiasm, concern and ambivalence in the Belgian public's attitude towards in-vitro gametogenesis.

Authors:  Heidi Mertes; Tina Goethals; Seppe Segers; Marie Huysentruyt; Guido Pennings; Veerle Provoost
Journal:  Reprod Biomed Soc Online       Date:  2021-11-25

Review 3.  Is there a valid ethical objection to the clinical use of in vitro-derived gametes?

Authors:  Kristian Galea
Journal:  Reprod Fertil       Date:  2021-11-23

4.  Enhancing the collectivist critique: accounts of the human enhancement debate.

Authors:  Tess Johnson
Journal:  Med Health Care Philos       Date:  2021-06-16
  4 in total

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