Dong Sun1, Hongli Song2, Zhongyang Shen3. 1. The First Central Clinical College, Tianjin Medical University, Tianjin, 300192, P.R.China. 2. Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin Key Laboratory of Organ Transplantation, Key Laboratory of Transplantation Medicine, Chinese Academy of Medical Sciences, Tianjin, 300192, P.R.China.hlsong26@163.com. 3. Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin Key Laboratory of Organ Transplantation, Key Laboratory of Transplantation Medicine, Chinese Academy of Medical Sciences, Tianjin, 300192, P.R.China.
Abstract
OBJECTIVE: To review the literature reports on research progress of Heme oxygenase 1 (HO-1) modified mesenchymal stem cells (MSCs). METHODS: The significance, effects, and related mechanism of HO-1 modification of MSCs were summarized by consulting the related literatures and reports of HO-1 modification of MSCs. RESULTS: HO-1 modification of MSCs has important research value. It can effectively enhance the anti-oxidative stress and anti-apoptotic properties of MSCs in complex internal environment after transplantation into vivo. It can also effectively enhance the immune regulation function of MSCs. It can improve the anti-injury, repair, and immune regulation effect of MSCs in various disease models and research fields. CONCLUSION: The basic research of HO-1 modified MSCs has made remarkable progress, which is expected to be applied in clinical trials and provide theoretical basis and reference value for stem cell therapy.
OBJECTIVE: To review the literature reports on research progress of Heme oxygenase 1 (HO-1) modified mesenchymal stem cells (MSCs). METHODS: The significance, effects, and related mechanism of HO-1 modification of MSCs were summarized by consulting the related literatures and reports of HO-1 modification of MSCs. RESULTS: HO-1 modification of MSCs has important research value. It can effectively enhance the anti-oxidative stress and anti-apoptotic properties of MSCs in complex internal environment after transplantation into vivo. It can also effectively enhance the immune regulation function of MSCs. It can improve the anti-injury, repair, and immune regulation effect of MSCs in various disease models and research fields. CONCLUSION: The basic research of HO-1 modified MSCs has made remarkable progress, which is expected to be applied in clinical trials and provide theoretical basis and reference value for stem cell therapy.
Authors: Colleen Davis; Amy Dukes; Michelle Drewry; Inas Helwa; Maribeth H Johnson; Carlos M Isales; William D Hill; Yutao Liu; Xingming Shi; Sadanand Fulzele; Mark W Hamrick Journal: Tissue Eng Part A Date: 2017-04-28 Impact factor: 3.845
Authors: Zheng Y Yu; Dan Ma; Zheng C He; Ping Liu; Jun Huang; Qin Fang; Jiang Y Zhao; Ji S Wang Journal: Exp Cell Res Date: 2017-10-28 Impact factor: 3.905