Literature DB >> 31295418

Cas13 Helps Bacteria Play Dead when the Enemy Strikes.

Senén D Mendoza1, Joseph Bondy-Denomy2.   

Abstract

How RNA-targeting CRISPR-Cas13 functions as a phage defense system has been mysterious. Recently in Nature, Meeske et al. (2019) demonstrate that Cas13 provides potent immunity to dsDNA phages without cutting their genome. By sensing phage transcripts and destroying RNA nonspecifically to arrest the cell into dormancy, Cas13 provides herd immunity.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 31295418      PMCID： PMC6842608          DOI： 10.1016/j.chom.2019.06.012

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  7 in total

1.  A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.

Authors:  Yan Zhang; David H Burkhardt; Silvi Rouskin; Gene-Wei Li; Jonathan S Weissman; Carol A Gross
Journal:  Mol Cell       Date:  2018-04-05       Impact factor: 17.970

2.  Dramatic decay of phage transcripts in lactococcal cells carrying the abortive infection determinant AbiB.

Authors:  R Parreira; S D Ehrlich; M C Chopin
Journal:  Mol Microbiol       Date:  1996-01       Impact factor: 3.501

3.  Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape.

Authors:  Nora C Pyenson; Kaitlyn Gayvert; Andrew Varble; Olivier Elemento; Luciano A Marraffini
Journal:  Cell Host Microbe       Date:  2017-08-17       Impact factor: 21.023

4.  The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair.

Authors:  Peter C Fineran; Tim R Blower; Ian J Foulds; David P Humphreys; Kathryn S Lilley; George P C Salmond
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-05       Impact factor: 11.205

5.  RNA editing with CRISPR-Cas13.

Authors:  David B T Cox; Jonathan S Gootenberg; Omar O Abudayyeh; Brian Franklin; Max J Kellner; Julia Joung; Feng Zhang
Journal:  Science       Date:  2017-10-25       Impact factor: 47.728

6.  C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.

Authors:  Omar O Abudayyeh; Jonathan S Gootenberg; Silvana Konermann; Julia Joung; Ian M Slaymaker; David B T Cox; Sergey Shmakov; Kira S Makarova; Ekaterina Semenova; Leonid Minakhin; Konstantin Severinov; Aviv Regev; Eric S Lander; Eugene V Koonin; Feng Zhang
Journal:  Science       Date:  2016-06-02       Impact factor: 47.728

7.  Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage.

Authors:  Alexander J Meeske; Sandra Nakandakari-Higa; Luciano A Marraffini
Journal:  Nature       Date:  2019-05-29       Impact factor: 49.962
  7 in total
  1 in total

Review 1.  RNA-targeting CRISPR-Cas systems.

Authors:  Sam P B van Beljouw; Jasper Sanders; Alicia Rodríguez-Molina; Stan J J Brouns
Journal:  Nat Rev Microbiol       Date:  2022-09-28       Impact factor: 78.297
  1 in total

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