Jinlian Shao1,2, Xuexi Yang3, Dunqiang Ren4, Yaling Luo2, Wenyan Lai5. 1. Department of ICU, The First Affiliated Hospital of Shantou University Medical College, Shantou, China. 2. Department of Respiratory Diseases, Nanfang Hospital, Guangzhou, China. 3. Department of Immunology, Southern Medical University, Guangzhou, China. 4. The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China. 5. Laborwatory of Cardiovascular Diseases, Nanfang Hospital, Guangzhou, China.
Abstract
BACKGROUND: This study was aimed to investigate the associations among Chitinase 3-like 1 (CHI3L1) polymorphisms, asthma and plasma YKL-40 levels in Chinese population. MATERIAL AND METHODS: Four CHI3L1 single nucleotide polymorphisms (SNPs) were genotyped. The YKL-40 level in plasma and eosinophil percentage in peripheral blood were quantified. RESULTS: A SNP (rs4950928) in the CHI3L1 promoter was associated with elevated plasma YKL-40 levels (p = .02), asthma (p = .042) and lung function (p = .029 to .002) in this Chinese population. Plasma YKL-40 levels were significantly elevated in patients with asthma compared to those in control subjects (p < .05). Plasma YKL-40 levels were significantly correlated with forced expiratory volume per cent (FEV1%) measurements (p < .05). Although plasma YKL-40 levels were decreased after treatment, the correlation with FEV1% still existed. CONCLUSIONS: CHI3L1 locus is a risk factor for asthma in Chinese population.
BACKGROUND: This study was aimed to investigate the associations among Chitinase 3-like 1 (CHI3L1) polymorphisms, asthma and plasma YKL-40 levels in Chinese population. MATERIAL AND METHODS: Four CHI3L1 single nucleotide polymorphisms (SNPs) were genotyped. The YKL-40 level in plasma and eosinophil percentage in peripheral blood were quantified. RESULTS: A SNP (rs4950928) in the CHI3L1 promoter was associated with elevated plasma YKL-40 levels (p = .02), asthma (p = .042) and lung function (p = .029 to .002) in this Chinese population. Plasma YKL-40 levels were significantly elevated in patients with asthma compared to those in control subjects (p < .05). Plasma YKL-40 levels were significantly correlated with forced expiratory volume per cent (FEV1%) measurements (p < .05). Although plasma YKL-40 levels were decreased after treatment, the correlation with FEV1% still existed. CONCLUSIONS: CHI3L1 locus is a risk factor for asthma in Chinese population.
Entities:
Keywords:
Asthma; CHI3L1; SNPs; YKL-40; lung function