Literature DB >> 31295

Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids.

A Baba, T Tsukamoto, T Matsuda, H Iwata.   

Abstract

Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++.

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Year:  1978        PMID： 31295     DOI： 10.1007/bf01922916

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  Cyclic nucleotide phosphodiesterase from a particulate fraction of rat brain. Evidence for an activator deficient form.

Authors:  T Lindl; G Chapman
Journal:  Biochem Biophys Res Commun       Date:  1976-08-23       Impact factor: 3.575

2.  Calcium-dependent cyclic nucleotide phosphodiesterase from brain identification of phospholipids as calcium-independent activators.

Authors:  D J Wolff; C O Brostrom
Journal:  Arch Biochem Biophys       Date:  1976-04       Impact factor: 4.013

3.  Effects of lipids on cyclic-nucleotide phosphodiesterases.

Authors:  C Bublitz
Journal:  Biochem Biophys Res Commun       Date:  1973-05-01       Impact factor: 3.575

4.  Separation of multiple molecular forms of cyclic adenosine-3',5'-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis.

Authors:  P Uzunov; B Weiss
Journal:  Biochim Biophys Acta       Date:  1972-09-19

5.  Cyclic 3',5'-nucleotide phosphodiesterase. Evidence for and properties of a protein activator.

Authors:  W Y Cheung
Journal:  J Biol Chem       Date:  1971-05-10       Impact factor: 5.157

6.  Cyclic 3',5'-nucleotide phosphodiesterase. Demonstration of an activator.

Authors:  W Y Cheung
Journal:  Biochem Biophys Res Commun       Date:  1970-02-06       Impact factor: 3.575

7.  Purification of a calcium-binding phosphoprotein from pig brain.

Authors:  D J Wolff; F L Siegel
Journal:  J Biol Chem       Date:  1972-07-10       Impact factor: 5.157

8.  The separation of synaptic vesicles from nerve-ending particles ('synaptosomes').

Authors:  V P Whittaker; I A Michaelson; R J Kirkland
Journal:  Biochem J       Date:  1964-02       Impact factor: 3.857

9.  A kinetic analysis of the cyclic nucleotide phosphodiesterase regulation by the endogenous protein activator. A study of rat brain and frog sympathetic chain.

Authors:  P Uzunov; R Lehne; A V Revuelta; M E Gnegy; E Costa
Journal:  Biochim Biophys Acta       Date:  1976-02-13

10.  Regulation of transsynaptically elicited increase of 3':5'-cyclic AMP by endogenous phosphodiesterase activator.

Authors:  M E Gnegy; E Costa; P Uzunov
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205
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