Literature DB >> 3129414

In vitro conditions for the self-polymerization of the microtubule-associated protein, tau factor.

E Montejo de Garcini1, J Avila.   

Abstract

One of the microtubule associated proteins, tau factor, that appears associated to the paired helical filaments of Alzheimer's disease presents, by itself, after urea treatment, the ability of polymerizing in vitro as tested by immunoelectronmicroscopy. These polymers resemble in their width and appearance those of the paired helical filaments. The conditions required for this assembly have been studied and determined the protein concentration needed, the influence of salt concentration and pH as well as the possible modifications (deamination, acylation) which may be implied in such in vitro polymerization.

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Year:  1987        PMID： 3129414     DOI： 10.1093/oxfordjournals.jbchem.a122187

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  10 in total

1.  Tau dephosphorylation at tau-1 site correlates with its association to cell membrane.

Authors:  M Arrasate; M Pérez; J Avila
Journal:  Neurochem Res       Date:  2000-01       Impact factor: 3.996

2.  Role of glycosaminoglycans in determining the helicity of paired helical filaments.

Authors:  M Arrasate; M Pérez; J M Valpuesta; J Avila
Journal:  Am J Pathol       Date:  1997-10       Impact factor: 4.307

3.  Dependency of microtubule-associated proteins (MAPs) for tubulin stability and assembly; use of estramustine phosphate in the study of microtubules.

Authors:  B Fridén; M Wallin
Journal:  Mol Cell Biochem       Date:  1991-07-10       Impact factor: 3.396

4.  Functional domains on chemically modified tau protein.

Authors:  G A Farías; C Vial; R B Maccioni
Journal:  Cell Mol Neurobiol       Date:  1993-04       Impact factor: 5.046

5.  Is tau a suitable therapeutical target in tauopathies?

Authors:  Elena Gomez de Barreda; Jesús Avila
Journal:  World J Biol Chem       Date:  2010-05-26

Review 6.  Tau function and dysfunction in neurons: its role in neurodegenerative disorders.

Authors:  Jesús Avila; Filip Lim; Francisco Moreno; Carlos Belmonte; A Claudio Cuello
Journal:  Mol Neurobiol       Date:  2002-06       Impact factor: 5.590

7.  Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Authors:  C M Wischik; M Novak; H C Thøgersen; P C Edwards; M J Runswick; R Jakes; J E Walker; C Milstein; M Roth; A Klug
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

8.  Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro.

Authors:  H Wille; G Drewes; J Biernat; E M Mandelkow; E Mandelkow
Journal:  J Cell Biol       Date:  1992-08       Impact factor: 10.539

Review 9.  Microglia in Alzheimer's Disease in the Context of Tau Pathology.

Authors:  Juan Ramón Perea; Marta Bolós; Jesús Avila
Journal:  Biomolecules       Date:  2020-10-14

10.  Are tau aggregates toxic or protective in tauopathies?

Authors:  Catherine M Cowan; Amrit Mudher
Journal:  Front Neurol       Date:  2013-08-13       Impact factor: 4.003
  10 in total

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