Literature DB >> 31292263

Translational impact of NIH-funded nonhuman primate research in transplantation.

Stuart J Knechtle1, Julia M Shaw2, Bernhard J Hering3, Kristy Kraemer2, Joren C Madsen4.   

Abstract

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Entities:  

Year:  2019        PMID： 31292263      PMCID： PMC7197021          DOI： 10.1126/scitranslmed.aau0143

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  79 in total

1.  Effect of mixed hematopoietic chimerism on cardiac allograft survival in cynomolgus monkeys.

Authors:  Tatsuo Kawai; A Benedict Cosimi; Siew Lin Wee; Stuart Houser; David Andrews; Hiroshi Sogawa; Joanne Phelan; Svetlan Boskovic; Ognjenka Nadazdin; Gregory Abrahamian; Robert B Colvin; David H Sach; Joren C Madsen
Journal:  Transplantation       Date:  2002-06-15       Impact factor: 4.939

Review 2.  Regulatory immune cells in transplantation.

Authors:  Kathryn J Wood; Andrew Bushell; Joanna Hester
Journal:  Nat Rev Immunol       Date:  2012-05-25       Impact factor: 53.106

3.  Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.

Authors:  Andrew M Posselt; Gregory L Szot; Lynda A Frassetto; Umesh Masharani; Mehdi Tavakol; Raj Amin; Joan McElroy; Marissa D Ramos; Robert K Kerlan; Lawrence Fong; Flavio Vincenti; Jeffrey A Bluestone; Peter G Stock
Journal:  Transplantation       Date:  2010-12-27       Impact factor: 4.939

4.  IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates.

Authors:  Edwin H Preston; He Xu; Kiran K Dhanireddy; Jonathan P Pearl; Frank V Leopardi; Matthew F Starost; Douglas A Hale; Allan D Kirk
Journal:  Am J Transplant       Date:  2005-05       Impact factor: 8.086

Review 5.  Transplant trials with Tregs: perils and promises.

Authors:  Qizhi Tang; Flavio Vincenti
Journal:  J Clin Invest       Date:  2017-06-30       Impact factor: 14.808

Review 6.  Memory T cells in organ transplantation: progress and challenges.

Authors:  Jaclyn R Espinosa; Kannan P Samy; Allan D Kirk
Journal:  Nat Rev Nephrol       Date:  2016-02-29       Impact factor: 28.314

7.  Sequential monitoring and stability of ex vivo-expanded autologous and nonautologous regulatory T cells following infusion in nonhuman primates.

Authors:  H Zhang; H Guo; L Lu; A F Zahorchak; R W Wiseman; G Raimondi; D K C Cooper; M B Ezzelarab; A W Thomson
Journal:  Am J Transplant       Date:  2015-03-17       Impact factor: 8.086

8.  A human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys: induction and maintenance therapy.

Authors:  T Aoyagi; K Yamashita; T Suzuki; M Uno; R Goto; M Taniguchi; T Shimamura; N Takahashi; T Miura; K Okimura; T Itoh; A Shimizu; H Furukawa; S Todo
Journal:  Am J Transplant       Date:  2009-06-10       Impact factor: 8.086

9.  Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism With Combined Donor Bone Marrow Transplantation.

Authors:  Tetsu Oura; Dicken S C Ko; Svjetlan Boskovic; John J O'Neil; Vaja Chipashvili; Maria Koulmanda; Kiyohiko Hotta; Kento Kawai; Ognjenka Nadazdin; R Neal Smith; A B Cosimi; Tatsuo Kawai
Journal:  Cell Transplant       Date:  2015-09-02       Impact factor: 4.064

10.  Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques.

Authors:  Raimon Duran-Struuck; Hugo P Sondermeijer; Leo Bühler; Paula Alonso-Guallart; Jonah Zitsman; Yojiro Kato; Anette Wu; Alicia N McMurchy; David Woodland; Adam Griesemer; Mercedes Martinez; Svetlan Boskovic; Tatsuo Kawai; A Benedict Cosimi; Yong-Guang Yang; Zheng Hu; Cheng-Shie Wuu; Andrea Slate; Markus Mapara; Sam Baker; Rafal Tokarz; Vivette D'Agati; Scott Hammer; Marcus Pereira; W Ian Lipkin; Thomas Wekerle; Megan Levings; Megan Sykes
Journal:  Transplantation       Date:  2017-02       Impact factor: 4.939
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  10 in total

1.  Initial experimental experience of triple-knockout pig red blood cells as potential sources for transfusion in alloimmunized patients with sickle cell disease.

Authors:  Takayuki Yamamoto; Mohamed H Bikhet; Marisa B Marques; Huy Q Nguyen; Yehua Cui; Mariyam Javed; Syed Sikandar Raza; David Ayares; Hayato Iwase; David K C Cooper; Hidetaka Hara
Journal:  Transfusion       Date:  2021-09-22       Impact factor: 3.157

2.  Single-Cell-Based High-Throughput Ig and TCR Repertoire Sequencing Analysis in Rhesus Macaques.

Authors:  Evan S Walsh; Tammy S Tollison; Hayden N Brochu; Brian I Shaw; Kayleigh R Diveley; Hsuan Chou; Lynn Law; Allan D Kirk; Michael Gale; Xinxia Peng
Journal:  J Immunol       Date:  2022-01-05       Impact factor: 5.426

Review 3.  Generation and functional assessment of nonhuman primate regulatory dendritic cells and their therapeutic efficacy in renal transplantation.

Authors:  Angus W Thomson; Mohamed B Ezzelarab
Journal:  Cell Immunol       Date:  2020-03-12       Impact factor: 4.868

Review 4.  Experimental modeling of desensitization: What have we learned about preventing AMR?

Authors:  Jean Kwun; Stuart Knechtle
Journal:  Am J Transplant       Date:  2020-06       Impact factor: 8.086

5.  Ex Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation, and Antiapoptotic Markers After Infusion Into ATG-lymphodepleted, Nonhuman Primate Heart Allograft Recipients.

Authors:  Mohamed B Ezzelarab; Hong Zhang; Kazuki Sasaki; Lien Lu; Alan F Zahorchak; Dirk J van der Windt; Helong Dai; Angelica Perez-Gutierrez; Jay K Bhama; Angus W Thomson
Journal:  Transplantation       Date:  2021-09-01       Impact factor: 5.385

6.  Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform.

Authors:  Ulrike Gerdemann; Ryan A Fleming; James Kaminski; Connor McGuckin; Xianliang Rui; Jennifer F Lane; Paula Keskula; Lorenzo Cagnin; Alex K Shalek; Victor Tkachev; Leslie S Kean
Journal:  Front Immunol       Date:  2022-01-26       Impact factor: 7.561

7.  Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque.

Authors:  Gavin I Ellis; Kimberly E Coker; Delaine W Winn; Mosha Z Deng; Divanshu Shukla; Vijay Bhoj; Michael C Milone; Wei Wang; Chengyang Liu; Ali Naji; Raimon Duran-Struuck; James L Riley
Journal:  Cell Rep Med       Date:  2022-05-11

8.  Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes.

Authors:  Amar Singh; Sabarinathan Ramachandran; Melanie L Graham; Saeed Daneshmandi; David Heller; Wilma Lucia Suarez-Pinzon; Appakalai N Balamurugan; Jeffrey D Ansite; Joshua J Wilhelm; Amy Yang; Ying Zhang; Nagendra P Palani; Juan E Abrahante; Christopher Burlak; Stephen D Miller; Xunrong Luo; Bernhard J Hering
Journal:  Nat Commun       Date:  2019-08-02       Impact factor: 14.919

9.  Characterization of 100 extended major histocompatibility complex haplotypes in Indonesian cynomolgus macaques.

Authors:  Cecilia G Shortreed; Roger W Wiseman; Julie A Karl; Hailey E Bussan; David A Baker; Trent M Prall; Amelia K Haj; Gage K Moreno; Maria Cecilia T Penedo; David H O'Connor
Journal:  Immunogenetics       Date:  2020-02-29       Impact factor: 2.846

10.  Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells.

Authors:  Shengli Song; Miriam Manook; Jean Kwun; Annette M Jackson; Stuart J Knechtle; Garnett Kelsoe
Journal:  Front Immunol       Date:  2021-07-13       Impact factor: 7.561
  10 in total

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