Literature DB >> 3129200

Hyperresistance to DNA damaging agents in yeast.

A Ruhland1, M Brendel, R H Haynes.   

Abstract

In order to study resistance to DNA damaging agents, yeast DNA segments conferring hyperresistance in this organism to such genotoxic agents were selected for among yeast cells transformed by a yeast genome library based on the multi-copy vector plasmid YEp13. Genetic variants hyperresistant to 4-nitroquinoline-N-oxide, formaldehyde, and alkylating agents were isolated and the respective hyperresistance determinants shown to co-segregate with the vector plasmid. Phenotypical characterization indicated different degrees of resistance, few cases of cross-resistance and differing structural stability of the cloned DNA. By transfer to E. coli and subsequent retransformation of yeast a number of plasmids was shown to stably carry the genetic information for hyperresistance.

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Year:  1986        PMID： 3129200     DOI： 10.1007/bf00420609

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  17 in total

1.  Mutagenesis by cytostatic alkylating agents in yeast strains of differing repair capacities.

Authors:  A Ruhland; M Brendel
Journal:  Genetics       Date:  1979-05       Impact factor: 4.562

Review 2.  Relationships between functionality and genetic toxicology of selected DNA-damaging agents.

Authors:  M Brendel; A Ruhland
Journal:  Mutat Res       Date:  1984-01       Impact factor: 2.433

Review 3.  Multidrug-resistance phenotype in Chinese hamster ovary cells.

Authors:  V Ling; N Kartner; T Sudo; L Siminovitch; J R Riordan
Journal:  Cancer Treat Rep       Date:  1983-10

4.  Genetic effects of formaldehyde in yeast. II. Influence of ploidly and of mutations affecting radiosensitivity on its lethal effect.

Authors:  R Chanet; C Izard; E Moustacchi
Journal:  Mutat Res       Date:  1976-04       Impact factor: 2.433

5.  Transformation of yeast.

Authors:  A Hinnen; J B Hicks; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

6.  Cloning and mapping of Saccharomyces cerevisiae photoreactivation gene PHR1.

Authors:  D Schild; J Johnston; C Chang; R K Mortimer
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

7.  The structure of transposable yeast mating type loci.

Authors:  K A Nasmyth; K Tatchell
Journal:  Cell       Date:  1980-03       Impact factor: 41.582

8.  Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.

Authors:  M Olsson; T Lindahl
Journal:  J Biol Chem       Date:  1980-11-25       Impact factor: 5.157

9.  The presence of a defective LEU2 gene on 2 mu DNA recombinant plasmids of Saccharomyces cerevisiae is responsible for curing and high copy number.

Authors:  E Erhart; C P Hollenberg
Journal:  J Bacteriol       Date:  1983-11       Impact factor: 3.490

10.  Molecular dosimetry of the chemical mutagen ethyl methanesulfonate. Quantitative comparison of the mutagenic potency in Neurospora crassa and Saccharomyces cerevisiae.

Authors:  A A van Zeeland; G R Mohn; C S Aaron; B W Glickman; M Brendel; F J de Serres; C Y Hung; H E Brockman
Journal:  Mutat Res       Date:  1983-01       Impact factor: 2.433
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  10 in total

1.  Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae.

Authors:  M Grey; M Schmidt; M Brendel
Journal:  Curr Genet       Date:  1996-04       Impact factor: 3.886

2.  A recessive mutant allele of the HNM1 gene of Saccharomyces cerevisiae is responsible for hyper-resistance to nitrogen mustard.

Authors:  E Haase; M Brendel
Journal:  Curr Genet       Date:  1990-10       Impact factor: 3.886

3.  Allelism of SNQ1 and ATR1, genes of the yeast Saccharomyces cerevisiae required for controlling sensitivity to 4-nitroquinoline-N-oxide and aminotriazole.

Authors:  P Gömpel-Klein; M Brendel
Journal:  Curr Genet       Date:  1990-07       Impact factor: 3.886

4.  Molecular characterization of the two genes SNQ and SFA that confer hyperresistance to 4-nitroquinoline-N-oxide and formaldehyde in Saccharomyces cerevisiae.

Authors:  P Gömpel-Klein; M Mack; M Brendel
Journal:  Curr Genet       Date:  1989-08       Impact factor: 3.886

5.  Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene.

Authors:  R Ben-Yaacov; S Knoller; G A Caldwell; J M Becker; Y Koltin
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

6.  Molecular structure and genetic regulation of SFA, a gene responsible for resistance to formaldehyde in Saccharomyces cerevisiae, and characterization of its protein product.

Authors:  E P Wehner; E Rao; M Brendel
Journal:  Mol Gen Genet       Date:  1993-03

7.  Isolation and characterization of additional genes influencing resistance to various mutagens in the yeast Saccharomyces cerevisiae.

Authors:  E Haase; J Servos; M Brendel
Journal:  Curr Genet       Date:  1992-04       Impact factor: 3.886

8.  Hyper-resistance to nitrogen mustard in Saccharomyces cerevisiae is caused by defective choline transport.

Authors:  Z Y Li; E Haase; M Brendel
Journal:  Curr Genet       Date:  1991-06       Impact factor: 3.886

9.  The SNQ3 gene of Saccharomyces cerevisiae confers hyper-resistance to several functionally unrelated chemicals.

Authors:  K Hertle; E Haase; M Brendel
Journal:  Curr Genet       Date:  1991-06       Impact factor: 3.886

10.  Genetic characterization of hyperresistance to formaldehyde and 4-nitroquinoline-N-oxide in the yeast Saccharomyces cerevisiae.

Authors:  M Mack; P Gömpel-Klein; E Haase; J Hietkamp; A Ruhland; M Brendel
Journal:  Mol Gen Genet       Date:  1988-02
  10 in total

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