Literature DB >> 3129165

Platelet-derived growth factor enhances demineralized bone matrix-induced cartilage and bone formation.

R Howes1, J M Bowness, G R Grotendorst, G R Martin, A H Reddi.   

Abstract

Subcutaneous implantation of demineralized bone matrix induces the local formation of cartilage and bone. In this study we have investigated the influence of adding various growth factors to the implant. Cartilage formation was monitored by measuring collagen II mRNA levels, and bone formation in the implant was assessed from alkaline phosphatase activity and calcium content. Supplements of the platelet-derived growth factor to implants in older rats increased and production of mRNA for collagen II, alkaline phosphatase activity, and the calcium content of the implant, whereas the other growth factors tested were without effect. The data suggest that under some conditions bone induction is submaximal and can be increased by local supplement of platelet-derived growth factor (PDGF). The present observations may have important therapeutic implications in the treatment of nonunions of fractures and impaired bone formation in the aged.

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Year:  1988        PMID： 3129165     DOI： 10.1007/bf02555836

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  21 in total

1.  A significant part of macrophage-derived growth factor consists of at least two forms of PDGF.

Authors:  K Shimokado; E W Raines; D K Madtes; T B Barrett; E P Benditt; R Ross
Journal:  Cell       Date:  1985-11       Impact factor: 41.582

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Journal:  Science       Date:  1965-11-12       Impact factor: 47.728

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Journal:  Cancer Res       Date:  1965-12       Impact factor: 12.701

4.  Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity.

Authors:  Y Martinet; P B Bitterman; J F Mornex; G R Grotendorst; G R Martin; R G Crystal
Journal:  Nature       Date:  1986 Jan 9-15       Impact factor: 49.962

5.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

6.  Epidermal keratin gene expressed in embryos of Xenopus laevis.

Authors:  E Jonas; T D Sargent; I B Dawid
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

7.  Platelet-derived growth factor stimulates bone resorption via a prostaglandin-mediated mechanism.

Authors:  A H Tashjian; E L Hohmann; H N Antoniades; L Levine
Journal:  Endocrinology       Date:  1982-07       Impact factor: 4.736

8.  Matrix-induced endochondral bone differentiation: influence of hypophysectomy, growth hormone, and thyroid-stimulating hormone.

Authors:  A H Reddi; N E Sullivan
Journal:  Endocrinology       Date:  1980-11       Impact factor: 4.736

9.  Effect of platelet-derived growth factor on DNA and protein synthesis in cultured rat calvaria.

Authors:  E Canalis
Journal:  Metabolism       Date:  1981-10       Impact factor: 8.694

10.  Collagenous bone matrix-induced endochondral ossification hemopoiesis.

Authors:  A H Reddi; W A Anderson
Journal:  J Cell Biol       Date:  1976-06       Impact factor: 10.539
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  10 in total

1.  Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.

Authors:  Roger K Long; Shigeki Nishida; Takuo Kubota; Yongmei Wang; Takeshi Sakata; Hashem Z Elalieh; Bernard P Halloran; Daniel D Bikle
Journal:  J Bone Miner Res       Date:  2011-12       Impact factor: 6.741

2.  A new simplified technique for producing platelet-rich plasma: a short technical note.

Authors:  S Marlovits; M Mousavi; C Gäbler; J Erdös; V Vécsei
Journal:  Eur Spine J       Date:  2004-06-22       Impact factor: 3.134

3.  Growth Factor Variation in Two Types of Autologous Platelet Biomaterials: PRP Versus PRF.

Authors:  Satyam Arora; Urvershi Kotwal; Mitu Dogra; Veena Doda
Journal:  Indian J Hematol Blood Transfus       Date:  2016-09-06       Impact factor: 0.900

4.  The effect of Emdogain and platelet-derived growth factor on the osteoinductive potential of hydroxyapatite tricalcium phosphate.

Authors:  R C Chan; V Marino; P M Bartold
Journal:  Clin Oral Investig       Date:  2011-10-28       Impact factor: 3.573

5.  An in vitro bioassay to assess biological activity in demineralized bone.

Authors:  L Wolfinbarger; Y Zheng
Journal:  In Vitro Cell Dev Biol Anim       Date:  1993-12       Impact factor: 2.416

6.  The use of platelet gel in postero-lateral fusion: preliminary results in a series of 14 cases.

Authors:  A Landi; R Tarantino; N Marotta; A G Ruggeri; M Domenicucci; L Giudice; S Martini; M Rastelli; G Ferrazza; N De Luca; G Tomei; R Delfini
Journal:  Eur Spine J       Date:  2011-03-17       Impact factor: 3.134

7.  Effect of bone marrow cell collection techniques and donor site locations on in-vitro growth of bone forming cells.

Authors:  Sung Min Chung; Eun-Bok Kim; So-Young Park; Min Chul Sung; Hyun Kook Youn; Myun-Whan Ahn
Journal:  Asian Spine J       Date:  2008-12-31

8.  Platelet-derived growth factor inhibits bone regeneration induced by osteogenin, a bone morphogenetic protein, in rat craniotomy defects.

Authors:  L J Marden; R S Fan; G F Pierce; A H Reddi; J O Hollinger
Journal:  J Clin Invest       Date:  1993-12       Impact factor: 14.808

9.  Do autologous growth factors enhance transforaminal lumbar interbody fusion?

Authors:  Hwan T Hee; Mohammad E Majd; Richard T Holt; Leann Myers
Journal:  Eur Spine J       Date:  2003-05-22       Impact factor: 3.134

10.  Bone progenitor cell deficits and the age-associated decline in bone repair capacity.

Authors:  R Quarto; D Thomas; C T Liang
Journal:  Calcif Tissue Int       Date:  1995-02       Impact factor: 4.333
  10 in total

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