| Literature DB >> 31290492 |
Xuekun Wang1, Yurui Xu2, Shujun Feng2, Xinyu Huang2, Xia Meng2, Jiao Chen3, Leilei Guo2, Junliang Ge2, Jikang Zhang2, Jianmei Chen2, Li Cheng2, Kai Gu4, Yu Zhang2, Qing Jiang5, Xinghai Ning2.
Abstract
We present a novel free fatty acid receptor 1 (FFA1) agonist, named PAFA, with a strong agonist potency (EC50 = 6.04 nM) and good serum stability. PAFA significantly stimulates insulin secretion in INS-1 cells in a glucose-dependent manner and exhibits high antihyperglycemic effects in db/db mice without adverse effects.Entities:
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Year: 2019 PMID： 31290492 DOI： 10.1039/c9cc04040d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222