Literature DB >> 31289213

Perspectives on the role of Wnt biology in cancer.

Christopher K Mirabelli1, Roel Nusse2, David A Tuveson3,4, Bart O Williams5.   

Abstract

Selected members of the Wnt signaling community met during a 4-day period in October 2018 to discuss the current challenges and opportunities associated with targeting the Wnt pathway for therapeutic benefit. A summary of key points of these discussions is presented in this report.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Entities:  

Year:  2019        PMID： 31289213     DOI： 10.1126/scisignal.aay4494

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  6 in total

1.  Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer.

Authors:  Efrat Dotan; Dana B Cardin; Heinz-Josef Lenz; Wells Messersmith; Bert O'Neil; Steven J Cohen; Crystal S Denlinger; Safi Shahda; Igor Astsaturov; Ann M Kapoun; Rainer K Brachmann; Shailaja Uttamsingh; Robert J Stagg; Colin Weekes
Journal:  Clin Cancer Res       Date:  2020-07-21       Impact factor: 12.531

2.  Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer.

Authors:  Monica Sharma; Deborah Molehin; Isabel Castro-Piedras; Edgar G Martinez; Kevin Pruitt
Journal:  Sci Rep       Date:  2019-11-07       Impact factor: 4.379

Review 3.  Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex.

Authors:  Youn-Sang Jung; Jae-Il Park
Journal:  Exp Mol Med       Date:  2020-02-10       Impact factor: 8.718

4.  Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway.

Authors:  Chaoxiong Zhang; Lei Huang; Jingyuan Xiong; Linshen Xie; Shi Ying; You Jia; Yuqin Yao; Xuejiao Song; Zhenguo Zeng; Jialing Yuan
Journal:  PLoS One       Date:  2021-03-04       Impact factor: 3.240

5.  Long non-coding RNA LINC00926 regulates WNT10B signaling pathway thereby altering inflammatory gene expression in PTSD.

Authors:  Marpe Bam; Xiaoming Yang; Jay P Ginsberg; Allison E Aiello; Monica Uddin; Sandro Galea; Prakash S Nagarkatti; Mitzi Nagarkatti
Journal:  Transl Psychiatry       Date:  2022-05-12       Impact factor: 7.989

Review 6.  WNT Signaling in Melanoma.

Authors:  Anna Gajos-Michniewicz; Malgorzata Czyz
Journal:  Int J Mol Sci       Date:  2020-07-09       Impact factor: 5.923
  6 in total

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