Literature DB >> 31287993

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

Stefan Mereiter1, Meritxell Balmaña1, Diana Campos1, Joana Gomes1, Celso A Reis2.   

Abstract

This review provides insights on the impact of glycosylation in cancer biology and its influence in the current approaches of targeted cancer therapies in the clinical setting. The roles of glycosylation in cancer signaling, tumor progression, and metastasis are reviewed as well as glycans and glycan-binding proteins in tumor immunomodulation. Moreover, the latest reports on glycans influencing targeted therapeutic approaches in cancer are summarized. Finally, we discuss the future challenges of the field, outlining potential applications of glycan-based biomarkers for patient stratification and strategies for improving personalized cancer treatment.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  cancer therapy; glycan-based; glycosylation; immunotherapy; targeted therapy

Mesh：

Substances：

Year:  2019        PMID： 31287993     DOI： 10.1016/j.ccell.2019.06.006

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


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