Fengdan Wang1, Haiping Zhang2, Chanyuan Wu3, Qian Wang3, Bo Hou1, Yi Sun4, Tobias Kober5, Tom Hilbert5, Yan Zhang1, Xiaofeng Zeng1, Zhengyu Jin3. 1. Department of Radiology, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, China. 2. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No.95 Yong'an Road, Xicheng District, Beijing, China. 3. Department of Rheumatology, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing, China. 4. MR Collaboration NE Asia, Siemens Healthcare, No.278 Zhouzhu Road, Pudong New Area, Shanghai, China. 5. Advanced Clinical Imaging Technology, Siemens Healthcare AG, Innovation Park EPFL-QI-E, CH-1015 Lausanne, Switzerland.
Abstract
OBJECTIVE: Dermatomyositis (DM) and polymyositis (PM) make up the largest group of potentially treatable myopathies and require early diagnosis. This study investigates whether the edema of thigh muscles in DM/PM can be quantitatively assessed by a novel accelerated T2 mapping technique-GRAPPATINI. METHODS: Three conventional MR sequences and GRAPPATINI accelerated T2 mapping of bilateral thighs from 20 patients (7 DM and 13 PM) and 10 healthy volunteers were prospectively carried out on a 3 T MR scanner. Afterwards, T2 values of 477 thigh muscles from the patients and the healthy controls were manually measured. In addition, the correlations between T2 values and serum muscle enzymes in patients were also analyzed. RESULTS: The new GRAPPATINI technique made quantitative T2 mapping of bilateral thighs feasible with a scanning time of only 2 min 18 s. Moreover, GRAPPATINI-generated T2 values of muscles from patients were markedly higher than those from healthy subjects (p < 0.001). GRAPPATINI accelerated T2 mapping appeared a more sensitive technique in that some DM/PM muscles appearing normal per conventional MRI had increased T2 relaxation time. Furthermore, GRAPPATINI-generated T2 values of DM/PM thigh muscles positively correlated with serum enzyme levels (p < 0.001), which reflected the severity of myopathy. CONCLUSION: GRAPPATINI can significantly shorten acquisition time of T2 mapping and may potentially be applied clinically in DM and PM. ADVANCES IN KNOWLEDGE: GRAPPATINI acceleration makes T2 mapping feasible in clinical practice in providing quantitative information regarding thigh muscle inflammation in DM and PM.
OBJECTIVE: Dermatomyositis (DM) and polymyositis (PM) make up the largest group of potentially treatable myopathies and require early diagnosis. This study investigates whether the edema of thigh muscles in DM/PM can be quantitatively assessed by a novel accelerated T2 mapping technique-GRAPPATINI. METHODS: Three conventional MR sequences and GRAPPATINI accelerated T2 mapping of bilateral thighs from 20 patients (7 DM and 13 PM) and 10 healthy volunteers were prospectively carried out on a 3 T MR scanner. Afterwards, T2 values of 477 thigh muscles from the patients and the healthy controls were manually measured. In addition, the correlations between T2 values and serum muscle enzymes in patients were also analyzed. RESULTS: The new GRAPPATINI technique made quantitative T2 mapping of bilateral thighs feasible with a scanning time of only 2 min 18 s. Moreover, GRAPPATINI-generated T2 values of muscles from patients were markedly higher than those from healthy subjects (p < 0.001). GRAPPATINI accelerated T2 mapping appeared a more sensitive technique in that some DM/PM muscles appearing normal per conventional MRI had increased T2 relaxation time. Furthermore, GRAPPATINI-generated T2 values of DM/PM thigh muscles positively correlated with serum enzyme levels (p < 0.001), which reflected the severity of myopathy. CONCLUSION: GRAPPATINI can significantly shorten acquisition time of T2 mapping and may potentially be applied clinically in DM and PM. ADVANCES IN KNOWLEDGE: GRAPPATINI acceleration makes T2 mapping feasible in clinical practice in providing quantitative information regarding thigh muscle inflammation in DM and PM.
Authors: Mark A Griswold; Peter M Jakob; Robin M Heidemann; Mathias Nittka; Vladimir Jellus; Jianmin Wang; Berthold Kiefer; Axel Haase Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Stefan Schanz; Jörg Henes; Anja Ulmer; Ina Kötter; Gerhard Fierlbeck; C D Claussen; Marius Horger Journal: Eur Radiol Date: 2012-07-29 Impact factor: 5.315
Authors: I Marie; L Lahaxe; O Benveniste; K Delavigne; D Adoue; L Mouthon; E Hachulla; J Constans; K Tiev; E Diot; H Levesque; O Boyer; F Jouen Journal: Br J Dermatol Date: 2009-08-29 Impact factor: 9.302
Authors: Lawrence Yao; Adrienne L Yip; Joseph A Shrader; Sepehr Mesdaghinia; Rita Volochayev; Anna V Jansen; Frederick W Miller; Lisa G Rider Journal: Rheumatology (Oxford) Date: 2015-09-27 Impact factor: 7.580
Authors: Marcus Raudner; Markus Schreiner; Tom Hilbert; Tobias Kober; Michael Weber; Reinhard Windhager; Siegfried Trattnig; Vladimir Juras Journal: Invest Radiol Date: 2020-11 Impact factor: 10.065