| Literature DB >> 31285615 |
Qingtao Sun1,2, Xiangning Li1,2,3, Miao Ren1,2, Mengting Zhao1,2, Qiuyuan Zhong1,2, Yuqi Ren4, Pan Luo1,2, Hong Ni1,2, Xiaoyu Zhang1,2, Chen Zhang1,2, Jing Yuan1,2,3, Anan Li1,2,3,5, Minmin Luo4, Hui Gong1,2,3,5, Qingming Luo6,7,8.
Abstract
The medial prefrontal cortex (mPFC) contains populations of GABAergic interneurons that play different roles in cognition and emotion. Their local and long-range inputs are incompletely understood. We used monosynaptic rabies viral tracers in combination with fluorescence micro-optical sectioning tomography to generate a whole-brain atlas of direct long-range inputs to GABAergic interneurons in the mPFC of male mice. We discovered that three subtypes of GABAergic interneurons in two areas of the mPFC are innervated by same upstream areas. Input from subcortical upstream areas includes cholinergic neurons from the basal forebrain and serotonergic neurons (which co-release glutamate) from the raphe nuclei. Reconstruction of single-neuron morphology revealed novel substantia innominata-anteromedial thalamic nucleus-mPFC and striatum-anteromedial thalamic nucleus-mPFC circuits. Based on the projection logic of individual neurons, we classified cortical and hippocampal input neurons into several types. This atlas provides the anatomical foundation for understanding the functional organization of the mPFC.Entities:
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Year: 2019 PMID： 31285615 DOI： 10.1038/s41593-019-0429-9
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884