| Literature DB >> 31285584 |
Robert A Edwards1,2, Alejandro A Vega3, Holly M Norman3, Maria Ohaeri3, Kyle Levi4, Elizabeth A Dinsdale3, Ondrej Cinek5, Ramy K Aziz6, Katelyn McNair7, Jeremy J Barr8, Kyle Bibby9, Stan J J Brouns10, Adrian Cazares11, Patrick A de Jonge10,12, Christelle Desnues13,14, Samuel L Díaz Muñoz15,16, Peter C Fineran17, Alexander Kurilshikov18, Rob Lavigne19, Karla Mazankova5, David T McCarthy20, Franklin L Nobrega10, Alejandro Reyes Muñoz21, German Tapia22, Nicole Trefault23, Alexander V Tyakht24,25, Pablo Vinuesa26, Jeroen Wagemans19, Alexandra Zhernakova18, Frank M Aarestrup27, Gunduz Ahmadov28, Abeer Alassaf29, Josefa Anton30, Abigail Asangba31, Emma K Billings3, Vito Adrian Cantu7, Jane M Carlton15, Daniel Cazares26, Gyu-Sung Cho32, Tess Condeff3, Pilar Cortés33, Mike Cranfield34, Daniel A Cuevas7, Rodrigo De la Iglesia35, Przemyslaw Decewicz36, Michael P Doane3, Nathaniel J Dominy37, Lukasz Dziewit36, Bashir Mukhtar Elwasila38, A Murat Eren39, Charles Franz32, Jingyuan Fu40, Cristina Garcia-Aljaro41, Elodie Ghedin15, Kristen M Gulino15, John M Haggerty3, Steven R Head42, Rene S Hendriksen27, Colin Hill43, Heikki Hyöty44, Elena N Ilina45, Mitchell T Irwin46, Thomas C Jeffries47, Juan Jofre41, Randall E Junge48, Scott T Kelley3, Mohammadali Khan Mirzaei49, Martin Kowalewski50, Deepak Kumaresan51, Steven R Leigh52, David Lipson3, Eugenia S Lisitsyna53, Montserrat Llagostera33, Julia M Maritz15, Linsey C Marr54, Angela McCann55, Shahar Molshanski-Mor56, Silvia Monteiro57, Benjamin Moreira-Grez51, Megan Morris3, Lawrence Mugisha58,59, Maite Muniesa41, Horst Neve32, Nam-Phuong Nguyen60, Olivia D Nigro61, Anders S Nilsson62, Taylor O'Connell63, Rasha Odeh29, Andrew Oliver64, Mariana Piuri65, Aaron J Prussin Ii54, Udi Qimron66, Zhe-Xue Quan67, Petra Rainetova68, Adán Ramírez-Rojas69, Raul Raya70, Kim Reasor3, Gillian A O Rice37, Alessandro Rossi12,71, Ricardo Santos57, John Shimashita54, Elyse N Stachler72, Lars C Stene22, Ronan Strain55, Rebecca Stumpf31, Pedro J Torres3, Alan Twaddle15, MaryAnn Ugochi Ibekwe73, Nicolás Villagra74, Stephen Wandro64, Bryan White31, Andy Whiteley51, Katrine L Whiteson64, Cisca Wijmenga18, Maria M Zambrano69, Henrike Zschach75, Bas E Dutilh76,77.
Abstract
Microbiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world's countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome.Entities:
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Year: 2019 PMID： 31285584 PMCID： PMC7440971 DOI： 10.1038/s41564-019-0494-6
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745