| Literature DB >> 3128339 |
J T Metz1, H H Holcomb, H Y Meltzer.
Abstract
The effect of the serotonin precursor DL-5-hydroxytryptophan (5-HTP) on the Hoffmann reflex recovery curve (HRRC) was studied in normal subjects and patients with affective illness. 5-HTP significantly decreased the HRRC in normal controls and in depressed and manic patients receiving treatment with lithium or antidepressants. 5-HTP increased the HRRC in unmedicated depressed and manic patients. These results provide further evidence for a serotonergic abnormality in the affective disorders.Entities:
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Year: 1988 PMID： 3128339 DOI： 10.1016/0006-3223(88)90007-8
Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382