Literature DB >> 312824

Activation of membrane phospholipase A by guinea pig lymphotoxin (GLT).

Y Kobayashi, J I Sawada, T Osawa.   

Abstract

The effect of GLT on target cells (L.P3 cells) labeled with radioactive fatty acids was examined. After incubation for 1 or 2 hr, no change in the survival ratio was observed, but radioactive fatty acid was released from phospholipids of the cells. When incubation was continued for 4 or 5 hr, the survival ratio was decreased with a concomitant increase of the radioactivity of triglyceride of the target cells and enhancement of calcium uptake into the target cells. These results could be explained by activation of membrane-bound phospholipase A after the binding of GLT to cell surface receptors.

Entities:  

Mesh:

Substances:

Year:  1979        PMID: 312824

Source DB:  PubMed          Journal:  J Immunol        ISSN: 0022-1767            Impact factor:   5.422


  8 in total

1.  Activation of CPP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function.

Authors:  M Higuchi; B B Aggarwal; E T Yeh
Journal:  J Clin Invest       Date:  1997-04-01       Impact factor: 14.808

2.  Enhanced thromboxane synthesis and vacuolization in human polymorphonuclear leucocytes induced by human lymphokine containing supernatants.

Authors:  P Conti; M Allegretta; T W Williams; M G Cifone; E Alesse; M Reale; E Boidi; R A Dempsey
Journal:  Clin Rheumatol       Date:  1985-12       Impact factor: 2.980

3.  Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy.

Authors:  S Ohshima; Y Saeki; T Mima; M Sasai; K Nishioka; H Ishida; M Shimizu; M Suemura; R McCloskey; T Kishimoto
Journal:  J Clin Immunol       Date:  1999-09       Impact factor: 8.317

4.  Characterization of lectin-induced cellular cytotoxicity mediated by mouse spleen cells and the role of lymphotoxin.

Authors:  J Sawada; T Osawa
Journal:  Immunology       Date:  1980-11       Impact factor: 7.397

5.  Human recombinant IL-1 receptor antagonist (IL-1Ra) inhibits leukotriene B4 generation from human monocyte suspensions stimulated by lipopolysaccharide (LPS).

Authors:  P Conti; M R Panara; R C Barbacane; M Bongrazio; R A Dempsey; M Reale
Journal:  Clin Exp Immunol       Date:  1993-03       Impact factor: 4.330

6.  Guinea-pig lymphotoxin-mediated cytotoxicity and activation of endogenous phospholipase A2.

Authors:  H Yagisawa; T Osawa
Journal:  Immunology       Date:  1982-11       Impact factor: 7.397

7.  The down-regulation of IL-6-stimulated fibrinogen steady state mRNA and protein levels by human recombinant IL-1 is not PGE2-dependent: effects of IL-1 receptor antagonist (IL-1RA).

Authors:  P Conti; L Bartle; R C Barbacane; M Reale; J D Sipe
Journal:  Mol Cell Biochem       Date:  1995-01-26       Impact factor: 3.396

8.  A possible role of glucocorticoids: an intrinsic inhibitor of the cytotoxic activity of tumor necrosis factor.

Authors:  S Abe; T Yamamoto; S Iihara; M Yamazaki; D Mizuno
Journal:  Jpn J Cancer Res       Date:  1988-03
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.