New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure.

Sarcopenia is an age-related geriatric syndrome that is characterized by a progressive loss of muscle mass, strength and function. Chronic heart failure (CHF), the final stage of various cardiovascular diseases, may be closely correlated with the occurrence of sarcopenia. Accumulating evidence has demonstrated that CHF can promote the development of sarcopenia through multiple pathophysiological mechanisms, including malnutrition, inflammation, hormonal changes, oxidative stress, autophagy, and apoptosis. Additionally, CHF can aggravate the adverse outcomes associated with sarcopenia, including falls, osteoporosis, frailty, cachexia, hospitalization, and mortality. Sarcopenia and CHF are mutually interacting clinical syndromes. Patients with these two syndromes seem to endure a double burden, with no particularly effective way to hinder their progression. However, the combination of physical exercise, nutritional supplements, and drug therapy may counteract the development of these maladies. In this review, we will summarize the latest progress in the pathogenesis and treatment of sarcopenia in patients with CHF.

1. Introduction

With an increasing proportion of the population being of advanced age, improving quality of life for the elderly has become a major challenge for geriatricians. The elderly often suffer from various geriatric syndromes, among which sarcopenia has been recognized as a new disease and has attracted significant worldwide attention 1. In recent years, the definition and diagnosis of sarcopenia have been continuously updated, and there is no consistent international standard. The current definition of sarcopenia is age-related loss of skeletal muscle quantity or quality and a decline in muscle strength and/or physical performance 2. The prevalence of sarcopenia ranges from 5 to 13% in persons aged 60 to 70 years and may even reach 50% in octogenarians, most of whom suffer from adverse events including falls, osteoporosis, a decline in quality of life, and increased mortality 3.

Chronic heart failure (CHF), another important geriatric syndrome, which is caused by cardiac contractile or diastolic dysfunction due to various cardiovascular disorders, including ischemic heart disease, hypertension, and cardiomyopathies 4. Cardiac pump dysfunction can reduce cardiac output, increase venous pressure, and is accompanied by ventricular remodeling, which causes progressive deterioration of the failing heart. Sarcopenia is a frequent co-morbidity among patients with CHF, which may adversely affect the prognosis of patients 5. The results of SICA-HF study showed that the prevalence of sarcopenia in CHF patients was nearly 20% higher than healthy individuals 6. Loss of peripheral skeletal muscle occurs early in most CHF patients regardless of reduced or preserved ejection fraction, which is closely related to a decline in physical activity 7.

Recently, accumulating evidence has suggested that CHF and sarcopenia can interact with each other and contribute to reduced physiological function and increased mortality in elderly patients. Although significant progress has been made in the pathological mechanisms of these two syndromes, there is still a lack of effective treatment for CHF patients with sarcopenia. This review will focus on the new insights into the pathogenesis and treatment of sarcopenia in CHF. We clarify how pathophysiological changes associated with CHF affect the muscle mass, structure, and function. In addition, we discuss how CHF aggravates the adverse outcomes of sarcopenia, including falls, osteoporosis, frailty, cachexia, hospitalization and mortality, which can facilitate the comprehensive management for patients with CHF and sarcopenia (Figure 1). Furthermore, we summarize the current treatment perspectives of these two geriatric syndromes. We not only emphasize the importance of physical exercise, nutritional supplements, and drug therapies, but also discuss the application prospects of some assistive technologies (Figure 2).

Figure 1

Pathogenesis of sarcopenia in chronic heart failure

Figure 2

Treatment of sarcopenia in chronic heart failure

2. Pathogenesis of sarcopenia in CHF

In CHF, decreased cardiac output and systemic congestion lead to reduced food intake and exercise capacity, promote the release of inflammatory factors, increase sympathetic excitability, and affect muscle-related hormone secretion. These factors work together in muscle tissue, resulting in a decline of skeletal muscle growth factor and increased oxidative damage, which enhances activity of the ubiquitin-proteasome system (UPS) and induces autophagy and apoptosis. These changes contribute to an imbalance in muscle protein synthesis and degradation, causing skeletal muscle wasting.

Skeletal muscle dysfunction in sarcopenia and CHF has some common molecular signatures but others are distinguished, and the direct causality remains unelucidated. For instance, the fiber type switch from type II to type I is observed in sarcopenia but type I atrophy is shown to occur in CHF. Although muscle mitochondrial dysfunction with regard to quality and quantity is a distinct feature in CHF, the direct evidence between such mitochondrial abnormalities and skeletal muscle atrophy remains undetermined.

2.1. Malnutrition

The etiology of sarcopenia in patients with CHF is multifactorial, and malnutrition is involved in its pathogenesis. In CHF, an elevated resting energy expenditure has been shown, and the negative balance between energy demand and expenditure leads to a catabolic state and causes protein-energy malnutrition 8, 9. Anorexia, a common symptom in patients with CHF, is independently associated with decreased muscle mass and strength 10. The causes of anorexia are complex and the physiological changes are diverse. Patients with CHF often have pulmonary and gastrointestinal edema, which can contribute to dysgeusia, nausea, and gastroenteropathy, eventually causing anorexia and malabsorption 11. In addition, some therapeutic drugs for CHF, especially digoxin, are also potential causes of anorexia 12.

2.2. Physical inactivity

Age-related decline in exercise capacity is the main factor for the loss of muscle mass and strength 13. Additionally, physical inactivity and long bed rest often exist in CHF patients and are associated with muscle wasting and dysfunction. Inactivity can attenuate the muscle protein synthesis through impairing mTORC1 signaling and amino acid transporter expression 14. Moreover, insulin sensitivity is also decreased in the elderly with long bed rest, which further negatively affects muscle homeostasis 15. Inflammation may also be associated with physical inactivity. The levels of inflammatory factors are significantly elevated in elderly patients with long bed rest, suggesting that higher inflammatory status may be an important factor for muscle catabolism following physical inactivity 16.

2.3. Low muscle blood flow

In CHF, low muscle blood flow, as evaluated by capillary density, is a potentially significant factor for lower muscle performance. Decreased cardiac output results in a decline in skeletal muscle blood flow and consequently affect muscle mass and strength. For patients with CHF, exercise can aggravate tissue ischemia and promote lactate accumulation. Low baseline and peak reactive hyperemia blood flow in forearm and leg often occurs in CHF, suggesting that CHF patients are more likely to suffer from endothelial dysfunction, which is one of the mechanisms of sarcopenia 17. Ischemic exercise can increase collateral blood flow in skeletal muscle. Blood flow restricted exercise training is effective in increasing muscular strength and size in older adults 18.

2.4. Inflammation

Patients with CHF often have chronic low-level systemic inflammation, which may exert sustained effects on skeletal muscle. Inflammatory mediators released into circulation further activate systemic inflammation and promote muscle atrophy. Elevated levels of inflammatory markers such as tumor necrosis factor-alpha, C-reactive protein, and interleukin-6 are correlated with decline in muscle mass and strength, which suggests a weight-associated pathway for inflammation in sarcopenia 19. Moreover, Sarcopenic obesity can promote the release of pro-inflammatory cytokines, which in turn negatively affect muscle mass and strength 20. Thus, low-grade inflammation contributes to skeletal muscle atrophy and dysfunction in patients with CHF.

2.5. Hormonal changes

In CHF, the decline in anabolic hormones and increase in catabolic hormones seem to be associated with sarcopenia. Insulin-like growth factor 1 (IGF-1) is a ligand necessary for growth hormone to produce physiological effects. Decrease in growth hormone and IGF-1 levels can lead to poor physical performance and sarcopenia 21, 22. Aerobic exercise training-induced activation of IGF-I/Akt/mTOR signaling pathway could counteract muscle wasting in heart failure mice 23. Angiotensin is elevated by neurohumoral compensation in patients with CHF and plays an important role in the pathological process of sarcopenia via multiple mechanisms. Angiotensin II infusion can induce muscle wasting via altered IGF-1 signaling, increased apoptosis, enhanced muscle protein breakdown, and reduced appetite 24. Patients with CHF often have low testosterone levels 25, which is associated with muscle mass loss, functional impairment, and adverse outcomes 26-28. In the cytoplasm, testosterone binds to androgen receptors and promotes protein transcription via the mitogen-activated protein kinase pathway, which increases muscle protein synthesis and muscle mass 29. Myostatin is a member of the transforming growth factor beta family and negatively regulates muscle mass. Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice 30. Myostatin has also been shown to be significantly upregulated in CHF patients 31. Elderly patients with CHF usually have lower ghrelin levels, which is a peptide produced in the stomach with various activities, including regulating appetite and promoting food intake and growth hormone release 32. Thus, the decreased level of ghrelin is associated with the occurrence of sarcopenia.

2.6. The UPS

In CHF, one of the main features of skeletal muscle atrophy is an imbalance of myofibrillar protein levels, probably due to increased protein degradation 33. UPS is the primary mechanism of protein degradation, and includes a coordinated enzymatic system of activation, binding, and protein targeting with ubiquitin, which is further degraded by proteasomes 34. This process is performed by a group of enzymes called E3 ubiquitin ligases, which recognize protein substrates to be ubiquitinated by the action of E2 enzymes. Atrogin-1 and MuRF-1 are two E3 ubiquitin ligases that are important regulators of ubiquitinmediated protein degradation in skeletal muscle. They are induced in response to myostatin/ transforming growth factor-β signaling and are critically involved in the pathogenesis of sarcopenia 35.

2.7. Autophagy

Autophagy activation is essential for cellular homeostasis by preventing accumulation of metabolic waste products. In CHF, the inability to remove damaged structures leads to increased oxidative stress, reduced ATP production, collapse of the cellular catabolic machinery, and cell death 36. Autophagy is a degradation pathway crucial for the removal of dysfunctional organelles and damaged macromolecules during aging process. Overweight can induce oxidative and endoplasmic reticulum stress in the elderly and force the aged muscle to increase requirements from autophagy mechanisms. Impaired autophagy may be the main reason of myogenesis dysfunction during aging, which ultimately contributes to agerelated skeletal muscle loss 37. Appropriate induction or accurate regulation of autophagic process and improved quality control of mitochondria through autophagy are required to maintain skeletal muscle mass 38.

2.8. Apoptosis

Myonuclear apoptosis is another molecular mechanism involved in muscle wasting and skeletal muscle atrophy 39,40. In skeletal muscle, apoptosis exhibits unique characteristics in view of the multinuclear nature of myocytes. Activation of the apoptotic cascade leads to the removal of individual myonuclei and the relative portion of sarcoplasm. This pathway causes fiber atrophy rather than wholesale cell death. In addition, apoptotic signaling can stimulate muscle protein degradation through the activation of the UPS, resulting in fiber atrophy, independent of myonuclear removal 41. Given that apoptotic signaling is required for protein degradation during muscle atrophy, muscle proteolysis and apoptosis are intimately connected 42. There are two mitochondrial subpopulations with different bioenergy and structure in skeletal myofibers: subsarcolemmal mitochondria and intermyofibrillar mitochondria, which may differentially participate in the pathogenesis of sarcopenia and display different susceptibility to apoptotic stimuli 43.

2.9. Oxidative stress

During the aging process, the production of reactive oxygen species (ROS) may drastically increase because of altered respiratory chain function and impaired antioxidant cellular defences 44. It has been reported that sarcopenia may be triggered by ROS which is involved in various cellular signaling processes. ROS can contribute to mitochondrial dysfunction and accelerate skeletal muscle damage and degeneration, which may consequently result in the occurrence of sarcopenia 45, 46. Recent findings have revealed that muscle oxidative damage is associated with the mechanisms underlying excitation-contraction coupling. The unbalance of Ca2+ transport that is present in the sarcopenic muscle might be due to the altered oxidative state of those components involved in Ca2+ release and uptake 45.

3. CHF aggravates the adverse outcomes of sarcopenia

3.1. Falls

As a complication of sarcopenia, falls affect the physical and mental health of the elderly and increase the burden on families and society. The ilSIRENTE study assessed the association between sarcopenia and 2-year risk of falls in older population and indicated that participants with sarcopenia had a higher risk of incident falls compared with non sarcopenic subjects 47. The underlying reason may be that sarcopenic individuals have poor stability and balance. Muscle fiber loss and atrophy with an inversion of type I to type II eventually result in decreased muscle mass and contractility 48. CHF is usually accompanied by a variety of symptoms in elderly patients, such as dyspnea, frailty, decreased activity, poor cognitive function, and postural hypotension 49-51, which make older people more likely to fall. In addition, the production of ROS is significantly increased in CHF, which changes the structure of contractile proteins myosin and actin, eventually reducing muscle contractility 48. Moreover, patients with CHF tend to have hypotension or need to take antihypertensive drugs. It has been reported that hypotension and use of antihypertensive medication are associated with an increased risk of falls among older adults 52, 53. However, the recent REGARDS study including 5236 participants taking antihypertensive medication suggested that serious fall injuries among older adults are not related to blood pressure or number of antihypertensive medication classes, but to indicators of frailty 54. In the treatment of CHF, we also need to pay attention to some drugs, such as digoxin and diuretics, which can potentially lead to falls 55.

3.2. Osteoporosis

Osteoporosis is a systemic bone disease characterized by low bone mass, bone microstructure damage, increased bone fragility, and easy fractures. Sarcopenia and osteoporosis are increasingly recognized as a “hazardous duet” and one is closely related to the other 56. Growing evidence has shown that sarcopenia is an independent risk factor for low bone mineral density (BMD) and fracture, and the mechanisms are complex, including the effects of mechanical load on cell behaviors of bone and surrounding tissues, as well as the biological mechanisms of endocrine regulation between muscles and bones 57, 58. A recent study involving 17,891 subjects with sarcopenia demonstrated that lean mass and grip strength were positively correlated with BMD and sarcopenia was related to low BMD and osteoporosis 59. Another research revealed that the components of clinical sarcopenia were strongly associated with osteoporosis, and grip strength was the most significant measurement 60. CHF can not only cause sarcopenia, but also make patients more prone to osteoporosis. For patients with CHF, long-term bed rest can lead to reduced outdoor activities, which has an adverse effect on the synthesis of vitamin D. In addition, long-term treatment with loop diuretics in CHF is associated with increased bone loss and fracture risk by inhibiting calcium reabsorption and increasing renal calcium excretion and bone turnover 61.

3.3. Frailty

Frailty is a clinical syndrome characterised by reduced physiological reserves affecting multiple organ systems and is related to increased risk of falls, fractures, hospitalisation and mortality 62. The prevalence of sarcopenia and frailty in the elderly increases with age, and the two syndromes have similar performance, but each has its own characteristics. Sarcopenia is manifested as a progressive loss of muscle mass and muscle strength/function, while frailty is a state of increased vulnerability to stressors and reduced capacity to maintain homeostasis. There is overlap between these two conditions, especially in terms of the physical aspects of the frailty phenotype: low grip strength, gait speed and muscle mass 63. Frailty often occurs in patients with CHF, and its prevalence varies from 18% to 54% depending on the study population and assessment methods 64. The coexistence of these two geriatric syndromes may probably result from a common pathological pathway. A key feature of frailty is loss of muscle mass and strength that is not directly proportional to age. The mechanisms that lead to this enhanced catabolic state include derangements in the neurohormonal, metabolic, immunological, and musculoskeletal systems 65. Peripheral loss of muscle tissue is a general finding in patients with CHF. The wasting syndrome in CHF affects all tissue compartments and is remarkably associated with neurohormonal and immunological abnormalities 66.

3.4. Cachexia

Cardiac cachexia is a syndrome involving progressive weight loss and alterations in body composition that carries a devastating prognosis in CHF 67. Reduced muscle mass is an important characteristic of cachexia. Sarcopenia and cachexia share some similar mechanisms, including inflammation, insulin resistance, protein metabolism, and mitochondrial dysfunction 68, 69. The main point to distinguish these two syndromes is weight loss, which is more predominant in cachexia rather than sarcopenia. Sarcopenia in CHF may eventually develop to cardiac cachexia, which is associated with poor prognosis 70, 71. A clinical study showed that the prevalence of cachexia was 10.5% in stable CHF and was lower than previously anticipated due to the novel treatment strategies 72. Cachexia and sarcopenia can overlap and be present in the same patient at the same time. Cachexia can be diagnosed with weighing scales only, whereas the detection of sarcopenia requires sophisticated body composition analysis 73.

3.5. Hospitalization and mortality

Sarcopenia, whether combined with CHF or alone, is a significant risk factor for hospitalization due to low muscle mass and strength. In the InCHIANTI study enrolling 538 sarcopenia participants, Cox regression analysis indicated that sarcopenia was associated with increased hospitalization and mortality after adjusting for potential confounders 74. Okamura et al. retrospectively reviewed 1119 patients who underwent heart valve surgery and found that patients with sarcopenia had decreased long-term survival and increased major adverse cardiovascular events 75. Muscle wasting is a frequent co-morbidity among patients with CHF. Sarcopenia and CHF can interact with each other and consequently contribute to reduced exercise capacity and adverse cardiovascular outcomes 76.

4. Treatments

4.1. Exercise

Currently, exercise is the most effective treatment for sarcopenia. Exercise training can exert beneficial effects on skeletal muscle through different mechanisms: mTORC1 activation, reduced oxidative stress, inhibition of inflammation, UPS inactivity, augmented mitochondrial biogenesis, increased IGF-1/myostatin ratio, and enhanced insulin sensitivity 77, 78. Aerobic and resistance exercise is associated with reduced hospitalization and improved quality of life in patients with CHF 79. Although sarcopenia is defined as a decrease in muscle mass and strength, resistance training may be the best physical exercise to prevent its occurrence and development, whereas aerobic exercise may be more suitable for cardiovascular fitness 80, 81. The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is involved in the regulation of signaling pathways that control mitochondrial biogenesis and function responsible for muscle morphology and physiological function 82. Physical exercise is a powerful stimulus to PGC-1α expression, which is crucial in protecting the muscle from several degradative and destructive processes, such as proteolysis, inflammation, oxidative damage, autophagy and apoptosis 83.

4.2. Nutrition

Besides exercise, nutrition should also be carefully evaluated, as a proper diet may be able to stimulate muscle anabolism and inhibit muscle catabolism. Protein is the most vital component for the elderly with regards to anabolic-catabolic balance, and excess protein intake can enhance not only muscle mass but also muscle function 84, 85. Some essential amino acids and their metabolites, particularly the branched-chain amino acids, might exert beneficial effects in the treatment of CHF, such as enhancing protein synthesis and inhibiting proteolysis 86. In addition, omega-3 polyunsaturated fatty acids might be an alternative therapeutic agent for sarcopenia due to their anti-inflammatory effects 87. Moreover, vitamin and mineral supplements are also essential for sarcopenic patients with CHF. Vitamin E has antioxidant properties 88 and vitamin D positively affects muscle strength 89. Mineral nutrients, especially calcium, magnesium and selenium, have been shown to prevent sarcopenia in observational studies 90.

4.3. Drug therapy

4.3.1. Standard CHF treatment

In the treatment of CHF, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers, beta-blockers, and aldosterone antagonists can not only relieve clinical symptoms, but also attenuate ventricular remodeling and reduce long-term mortality 91. ACE inhibitors have been shown to exert beneficial effects on sarcopenia via multiple biological pathways. They can improve mitochondrial function, increase IGF-1 levels, enhance insulin sensitivity, and promote glucose uptake in skeletal muscles 92. However, a recent meta-analysis suggested that ACE inhibitors did not improve muscle strength and function in the elderly 93. In addition, aldosterone antagonists such as spironolactone may delay the progression of sarcopenia by reducing skeletal myocyte apoptosis, improving vascular endothelial function and enhancing muscle contractility 94. Furthermore, beta-blockers have been reported to increase body fat mass and improve cardiac function and exercise capacity in CHF patients 95. For diastolic heart failure, there is currently no standard therapeutic strategy. Biomarkers of myocardial fibrosis, such as soluble source of tumorigenicity 2, growth differentiation factor 15, and galectin-3 play critical roles in the diagnosis and treatment of CHF with preserved ejection fraction 96. Coronary heart disease is an important cause of CHF and statins are essential therapeutic drugs. Along with the main effect of cholesterol lowering, statins have some ancillary actions that may be relevant to sarcopenia. The potential mechanisms of statin-mediated muscle dysfunction involve IGF-1, inflammation, the UPS, apoptosis, and myostatin 97.

4.3.2. Hormonal treatment

4.3.2.1. Testosterone

The testosterone levels are significantly reduced in male patients with CHF 98. Previous randomized controlled trials demonstrated that testosterone replacement therapy could improve muscle performance, exercise capacity, and insulin resistance in elderly patients with moderately severe CHF 99,100. However, people worry about its various side effects, including increased risk of prostatic hyperplasia and cardiovascular events. Thus, selective androgen receptor modulator (SARM) is a theoretically better treatment strategy, as it has negligible side effects and equivalent function. Although SARMs have been shown to have positive effects on sarcopenia in some preclinical studies, large-scale trials are needed to confirm their efficacy and safety 101.

4.3.2.2. Growth hormone

Growth hormone replacement therapy can prevent sarcopenia by a dual mechanism: improvement of protein balance and antioxidant defense 102. For patients with CHF, the clinical effectiveness of growth hormone has not been confirmed. Osterziel et al. conducted a randomized trial involving 50 CHF patients with dilated cardiomyopathy and found a significant increase in left ventricular mass in patients with growth hormone treatment, but this was not accompanied by an improvement in clinical status 103. However, another placebo-controlled study demonstrated that recombinant human growth hormone had no significant effect on cardiac function, exercise capacity or neuroendocrine activation in patients with CHF 104.

4.3.2.3. Ghrelin

Ghrelin may be a promising therapeutic target for sarcopenia due to its positive effects on gastric motility, food intake, and growth hormone secretion. A previous study indicated that ghrelin treatment could effectively reduce the physical decline in sarcopenic mouse model through muscular enhancement and mitochondrial activation 105. Moreover, a clinical study suggested that ghrelin administration could improve left ventricular function and exercise capacity, and increase muscle strength and lean body mass in patients with CHF 106. However, some ghrelin analogues have been shown to improve body weight but have no effect on cardiac function in the rat model of CHF 107.

4.3.2.4. Insulin

Insulin can promote muscle protein synthesis by increasing muscle blood flow, amino acid delivery and availability 108. A population-based study from Korea revealed that obese men with sarcopenia exhibited a significantly high risk of insulin resistance 109. Additionally, patients with CHF are more prone to insulin resistance due to changes in neuroendocrine, inflammation, and inactivity 110. Insulin supplementation may be beneficial for sarcopenic patients with CHF. However, a recent large-scale study demonstrated that insulin treatment might cause worse outcomes in patients with CHF and diabetes because of sodium retention and hypoglycemia 111. Despite this, whether insulin use is associated with poor prognosis of CHF should be further investigated.

4.3.2.5. Thyroid hormone

Thyroid hormone is an important endocrine regulator with multiple biological functions. One major target of thyroid hormone is the skeletal muscle. They participate in a variety of biochemical events involved in the regulation of muscle mass and function 112. It has been proved that overt and subclinical hyperthyroidism are related to the decline in muscle mass and strength 113. In addition, elevated levels of thyroid-stimulating hormone are associated with increased hospitalization and mortality in patients with CHF 114. However, the relationship between subclinical hypothyroidism and CHF is still controversial 115. Thus, for CHF patients with sarcopenia, it is vital to maintain thyroid hormone at normal levels.

4.3.3. Myostatin inhibition

Myostatin is a member of the transforming growth factor beta family that is highly expressed in skeletal muscle 116. It has been suggested that myostatin is a primary target of pharmacological interventions in muscle atrophy and wasting 117,118. Therapeutic approaches have been taken to inhibit myostatin signaling both preclinically and clinically. Several myostatin inhibitors have been developed and used in clinical trials over the past decade. The results were disappointing and there was only limited effectiveness. However, a recent study indicated that bimagrumab may be a surprise. Bimagrumab treatment for 16 weeks was associated with increased muscle mass and strength in participants with sarcopenia and improved mobility in those with slow walking speed 119. Further studies are needed to evaluate whether bimagrumab administration in the elderly with reduced skeletal muscle mass and impaired physical function could contribute to significant improvement in functional capacity and substantial prolongation of independence.

4.4. Assistive treatment

Elderly people who lack exercise or are unable to exercise due to a physical disability can undergo physical therapy, such as hydrotherapy, whole body vibration therapy, or functional electrical stimulation. Additionally, assistive technologies such as mobility aids, bathroom equipment, prostheses, communication devices, and specialized computer software and hardware also can prevent and/or treat muscle wasting, but the specific mechanisms and application conditions need to be further clarified 120.

5. Conclusions

The diagnosis of sarcopenia has no uniform standard due to the influence of race, age, and gender. Currently, there is no particularly effective treatment strategy for this disease. CHF is a complex clinical syndrome with hundreds of years of history. Unfortunately, it is still a fortress that is difficult to overcome in the cardiovascular field. In recent years, the relationship between sarcopenia and CHF has not been fully understood. Patients with CHF are often accompanied by sarcopenia, which can cause a severe decline in quality of life and an increase in mortality. The diagnosis of sarcopenia depends on the evaluation of muscle mass, strength, and function. In addition, more specific biomarkers need to be identified for the diagnosis and staging of sarcopenia. Current drug development for the treatment of sarcopenia and CHF is still in the infancy stage, and the effectiveness and safety of the drugs are uncertain. Some representative clinical trials are presented in Table 1. In the future, the combination of physical exercise, nutritional supplements, and drug therapy may have the potential to counteract sarcopenia in CHF. In summary, it is necessary to screen for sarcopenia in patients with CHF. By establishing early evaluation methods and comprehensive treatment strategies, we can effectively delay the progression of sarcopenia in CHF and improve the life quality of patients.

Table 1

Summary of some clinical trials included in this review.

Study	Patients	Duration	Treatment	Main findings
Caminiti et al 99	70 elderly male patients with stable CHF, LVEF<40%, NYHA class II to III	12 weeks	Intramuscular long-acting testosterone undecanoate (1000 mg)	Improvements in exercise capacity, muscle strength, glucose metabolism, and baroreflex sensitivity
Malkin et al 100	76 male patients with stable CHF	12 months	A single 5 mg testosterone patch at night, replaced every 24 h	Improved functional capacity and symptoms
Osterziel et al 103	50 CHF patients with dilated cardiomyopathy, LVEF<45%	12 weeks	Subcutaneous injection of rhGH (2 IU) daily	Increase in left-ventricular mass; no change in NYHA class, LVEF, or 6‑MWD
Isgaard et al 104	22 patients with CHF, LVEF<45%, NYHA class II to III	3 months	Subcutaneous injection of rhGH (0.25 IU/kg/week) every evening	No effect on cardiac function, exercise capacity, or neuroendocrine activation
Nagaya et al 106	18 patients with stable CHF, LVEF<35%	3 weeks	Intravenous ghrelin (2 μg/kg twice a day)	Increase in LVEF, 6‑MWD, pVO2, muscle strength, and lean body mass
Rooks et al 119	40 elderly people with sarcopenia	16 weeks	Intravenous bimagrumab 30 mg/kg	Increased muscle mass and strength and improved mobility

CHF = chronic heart failure; LVEF = left ventricular ejection fraction; NYHA = New York Heart Association; pVO2 = peak oxygen consumption; rhGH = recombinant human growth hormone; 6MWD = 6-min walk distance.