Dana Ivancovsky-Wajcman1, Naomi Fliss-Isakov2, Federico Salomone3, Muriel Webb4, Oren Shibolet5, Revital Kariv6, Shira Zelber-Sagi7. 1. School of Public Health, University of Haifa, Haifa, Israel. Electronic address: szelber-s@univ.haifa.ac.il. 2. Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel. Electronic address: naomifl@tlvmc.gov.il. 3. Division of Gastroenterology, Ospedale di Acireale, Azienda Sanitaria Provinciale di Catania, Catania, Italy. Electronic address: federicosalomone@rocketmail.com. 4. Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: murielw@tlvmc.gov.il. 5. Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: orensh@tlvmc.gov.il. 6. Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel; The Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: revitalk@tlvmc.gov.il. 7. School of Public Health, University of Haifa, Haifa, Israel; Department of Gastroenterology, Tel-Aviv Medical Center, Tel-Aviv, Israel. Electronic address: zelbersagi@bezeqint.net.
Abstract
BACKGROUND & AIMS: Although antioxidants have a protective potential in nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), there is limited evidence regarding the role of dietary intake of antioxidants. The aim was to test the association between dietary vitamins E and C intake and NAFLD, NASH and fibrosis markers. METHODS: Cross-sectional study of a large cohort of subjects undergoing colonoscopy. The presence of NAFLD was evaluated by ultrasonography. The level of steatosis was defined using SteatoTest, moderate-severe NASH using new quantitative NashTest and borderline-significant fibrosis ≥ F1-F2 using FibroTest. Nutritional intake was measured by food frequency questionnaire (FFQ). RESULTS: Overall, 789 subjects were included (52.6% men, age 58.83 ± 6.58 years), 714 had reliable FibroMax. Adjusting for BMI, dietary and lifestyle factors, the upper tertile of vitamin E intake/1000 Kcal was associated with lower odds of NASH (OR = 0.64, 0.43-0.94, P = 0.024). There was an inverse association between reaching the recommended vitamin E intake and NASH (OR = 0.48, 0.30-0.77, P = 0.002). The upper tertile of vitamin C intake/1000 Kcal was associated with lower odds of NAFLD and NASH (OR = 0.68, 0.47-0.99, P = 0.045; OR = 0.57, 0.38-0.84, P = 0.004, respectively). Both vitamins were related with the level of steatosis according to SteatoTest. CONCLUSION: Vitamin E and C intake may be protective from NAFLD-related liver damage.
BACKGROUND & AIMS: Although antioxidants have a protective potential in nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), there is limited evidence regarding the role of dietary intake of antioxidants. The aim was to test the association between dietary vitamins E and C intake and NAFLD, NASH and fibrosis markers. METHODS: Cross-sectional study of a large cohort of subjects undergoing colonoscopy. The presence of NAFLD was evaluated by ultrasonography. The level of steatosis was defined using SteatoTest, moderate-severe NASH using new quantitative NashTest and borderline-significant fibrosis ≥ F1-F2 using FibroTest. Nutritional intake was measured by food frequency questionnaire (FFQ). RESULTS: Overall, 789 subjects were included (52.6% men, age 58.83 ± 6.58 years), 714 had reliable FibroMax. Adjusting for BMI, dietary and lifestyle factors, the upper tertile of vitamin E intake/1000 Kcal was associated with lower odds of NASH (OR = 0.64, 0.43-0.94, P = 0.024). There was an inverse association between reaching the recommended vitamin E intake and NASH (OR = 0.48, 0.30-0.77, P = 0.002). The upper tertile of vitamin C intake/1000 Kcal was associated with lower odds of NAFLD and NASH (OR = 0.68, 0.47-0.99, P = 0.045; OR = 0.57, 0.38-0.84, P = 0.004, respectively). Both vitamins were related with the level of steatosis according to SteatoTest. CONCLUSION:Vitamin E and C intake may be protective from NAFLD-related liver damage.
Authors: Tanyaporn K Kaenkumchorn; Melissa A Merritt; Unhee Lim; Loïc Le Marchand; Carol J Boushey; John A Shepherd; Lynne R Wilkens; Thomas Ernst; Johanna W Lampe Journal: J Nutr Date: 2021-11-02 Impact factor: 4.687
Authors: Domenico Ferro; Francesco Baratta; Daniele Pastori; Nicholas Cocomello; Alessandra Colantoni; Francesco Angelico; Maria Del Ben Journal: Nutrients Date: 2020-09-10 Impact factor: 5.717