Narendra K Bagri1, Vidya K Saurabh1, Sriparna Basu1, Ashok Kumar2. 1. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. 2. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. ashokkumar_bhu@hotmail.com.
Abstract
OBJECTIVE: To compare the incidence of hyponatremia during the first 48 h in hospitalized children receivingnormal saline vs. N/2 saline as maintenance intravenous fluid. METHODS: This open label, randomized controlled trial to compare the incidence of hyponatremia in hospitalized children receivingnormal saline (0.9% sodium chloride in 5% dextrose) vs. N/2 saline (0.45% sodium chloride in 5% dextrose) as maintenance fluid was conducted from December 2014 through November 2015 in a tertiary care teaching hospital. Children between 1 mo and 18 y requiring maintenance intravenous fluids were randomized to receive normal saline with 5% dextrose (n = 75) or N/2 saline with 5% dextrose (n = 75). RESULTS: Both groups were comparable for demographic variables and illness severity at baseline. Incidence of hyponatremia at 24 h of hospitalization was comparable between normal saline and N/2 saline group, 3(4%) vs. 6(8%) cases, respectively; p value 0.494. Mean serum sodium levels were marginally higher in normal saline group (138.3 ± 6.0 mEq/L) as compared with N/2 saline group (135.1 ± 4.4 mEq/L) (p value <0.01) at 24 h of hospitalization. Incidence of hyponatremia at 48 h and hypernatremia at 24 and 48 h was comparable in two groups. CONCLUSIONS: The use of either N/2 saline or normal saline in sick children at standard maintenance fluid rates is associated with low but comparable incidence of hypo or hypernatremia in first 24 h of hospitalization. Both types of fluids appear acceptable in hospitalized sick children.
RCT Entities:
OBJECTIVE: To compare the incidence of hyponatremia during the first 48 h in hospitalized children receiving normal saline vs. N/2 saline as maintenance intravenous fluid. METHODS: This open label, randomized controlled trial to compare the incidence of hyponatremia in hospitalized children receiving normal saline (0.9% sodium chloride in 5% dextrose) vs. N/2 saline (0.45% sodium chloride in 5% dextrose) as maintenance fluid was conducted from December 2014 through November 2015 in a tertiary care teaching hospital. Children between 1 mo and 18 y requiring maintenance intravenous fluids were randomized to receive normal saline with 5% dextrose (n = 75) or N/2 saline with 5% dextrose (n = 75). RESULTS: Both groups were comparable for demographic variables and illness severity at baseline. Incidence of hyponatremia at 24 h of hospitalization was comparable between normal saline and N/2 saline group, 3(4%) vs. 6(8%) cases, respectively; p value 0.494. Mean serum sodium levels were marginally higher in normal saline group (138.3 ± 6.0 mEq/L) as compared with N/2 saline group (135.1 ± 4.4 mEq/L) (p value <0.01) at 24 h of hospitalization. Incidence of hyponatremia at 48 h and hypernatremia at 24 and 48 h was comparable in two groups. CONCLUSIONS: The use of either N/2 saline or normal saline in sick children at standard maintenance fluid rates is associated with low but comparable incidence of hypo or hypernatremia in first 24 h of hospitalization. Both types of fluids appear acceptable in hospitalized sick children.
Entities:
Keywords:
Children; Hypotonic fluids; Maintenance fluids; N/2 saline; Normal saline
Authors: Leonard G Feld; Daniel R Neuspiel; Byron A Foster; Michael G Leu; Matthew D Garber; Kelly Austin; Rajit K Basu; Edward E Conway; James J Fehr; Clare Hawkins; Ron L Kaplan; Echo V Rowe; Muhammad Waseem; Michael L Moritz Journal: Pediatrics Date: 2018-12 Impact factor: 7.124
Authors: Yeonhee Lee; Kyung Don Yoo; Seon Ha Baek; Yang Gyun Kim; Hyo Jin Kim; Ji Young Ryu; Jin Hyuk Paek; Sang Heon Suh; Se Won Oh; Jeonghwan Lee; Jong Hyun Jhee; Jin-Soon Suh; Eun Mi Yang; Young Ho Park; Yae Lim Kim; Miyoung Choi; Kook-Hwan Oh; Sejoong Kim Journal: Kidney Res Clin Pract Date: 2022-07-28