Hyun Min Koh1, Hyo Jung An1, Gyung Hyuck Ko2,3,4, Jeong Hee Lee2,3,4, Jong Sil Lee2,3,4, Dong Chul Kim2,3,4, Deok Ha Seo5, Dae Hyun Song6,2,3. 1. Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea. 2. Gyeongsang National University School of Medicine, Jinju, Republic of Korea. 3. Gyeongsang Institute of Health Science, Jinju, Republic of Korea. 4. Department of Pathology, Gyeongsang National University Hospital, Jinju, Republic of Korea. 5. Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea. 6. Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea golgy@hanmail.net.
Abstract
BACKGROUND/AIM: Multiple primary malignant tumors are common in patients with renal cell carcinoma. However, reports on the factors that can identify patients with a risk for subsequent primary malignancies have been lacking. This study aimed to investigate whether myoferlin expression can be used as a potential marker to predict subsequent primary malignancies in patients with clear cell renal cell carcinoma (ccRCC). MATERIALS AND METHODS: We evaluated the relationship of subsequent primary malignancies with clinicopathological factors and myoferlin expression in 152 patients with ccRCC, and we analyzed the strength of the association with myoferlin expression. RESULTS: The development of subsequent primary malignancies exhibited significant correlation with patient age (p=0.029), sex (p=0.015), T stage (p<0.001), and myoferlin expression (p=0.017). Furthermore, myoferlin hyperexpression was determined as an independent risk factor for developing a subsequent primary malignant tumor in patients with ccRCC (odds ratio(OR), 2.485, 95% Confidence Interval(CI)=1.052-5.870, p=0.038). CONCLUSION: Myoferlin hyperexpression can be a useful marker for predicting the development of subsequent primary malignancies in patients with ccRCC. Copyright
BACKGROUND/AIM: Multiple primary malignant tumors are common in patients with renal cell carcinoma. However, reports on the factors that can identify patients with a risk for subsequent primary malignancies have been lacking. This study aimed to investigate whether myoferlin expression can be used as a potential marker to predict subsequent primary malignancies in patients with clear cell renal cell carcinoma (ccRCC). MATERIALS AND METHODS: We evaluated the relationship of subsequent primary malignancies with clinicopathological factors and myoferlin expression in 152 patients with ccRCC, and we analyzed the strength of the association with myoferlin expression. RESULTS: The development of subsequent primary malignancies exhibited significant correlation with patient age (p=0.029), sex (p=0.015), T stage (p<0.001), and myoferlin expression (p=0.017). Furthermore, myoferlin hyperexpression was determined as an independent risk factor for developing a subsequent primary malignant tumor in patients with ccRCC (odds ratio(OR), 2.485, 95% Confidence Interval(CI)=1.052-5.870, p=0.038). CONCLUSION:Myoferlin hyperexpression can be a useful marker for predicting the development of subsequent primary malignancies in patients with ccRCC. Copyright
Authors: M Qiu; Y Y Lian; M Lu; B S Wang; X J Tian; J Lu; C Liu; S D Zhang; M Jiang; L L Ma Journal: Beijing Da Xue Xue Bao Yi Xue Ban Date: 2022-08-18