Literature DB >> 3127963

Ketoconazole promotes parasitological cure of mice infected with Trypanosoma cruzi.

R E McCabe1, J S Remington, F G Araujo.   

Abstract

Administration of 120 mg/kg/day of ketoconazole for 9 weeks resulted in parasitological cure of at least 78.5% of mice infected with 10(5) blood trypanosomes of Trypanosoma cruzi, strain Y. These results and the fact that ketoconazole is widely used in humans for prolonged therapy of fungal infections without significant side effects strongly suggest that further evaluation of ketoconazole for treatment of Chagas disease is highly desirable.

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Year:  1987        PMID： 3127963     DOI： 10.1016/0035-9203(87)90430-5

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  8 in total

1.  Antiproliferative effects and mechanism of action of ICI 195,739, a novel bis-triazole derivative, on epimastigotes and amastigotes of Trypanosoma (Schizotrypanum) cruzi.

Authors:  J A Urbina; K Lazardi; T Aguirre; M M Piras; R Piras
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

2.  Ultrastructural alterations induced by ICI 195,739, a bis-triazole derivative with strong antiproliferative action against Trypanosoma (Schizotrypanum) cruzi.

Authors:  K Lazardi; J A Urbina; W de Souza
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

3.  Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.

Authors:  R A Maldonado; J Molina; G Payares; J A Urbina
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

4.  Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.

Authors:  J A Urbina; K Lazardi; E Marchan; G Visbal; T Aguirre; M M Piras; R Piras; R A Maldonado; G Payares; W de Souza
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

5.  Gamma interferon suppresses acute and chronic Trypanosoma cruzi infection in cyclosporin-treated mice.

Authors:  R McCabe; S Meagher; B Mullins
Journal:  Infect Immun       Date:  1991-05       Impact factor: 3.441

6.  Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.

Authors:  J A Urbina; G Payares; L M Contreras; A Liendo; C Sanoja; J Molina; M Piras; R Piras; N Perez; P Wincker; D Loebenberg
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

Review 7.  Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host.

Authors:  Vitor Sueth-Santiago; Debora Decote-Ricardo; Alexandre Morrot; Celio Geraldo Freire-de-Lima; Marco Edilson Freire Lima
Journal:  World J Biol Chem       Date:  2017-02-26

8.  Induction of resistance to azole drugs in Trypanosoma cruzi.

Authors:  F S Buckner; A J Wilson; T C White; W C Van Voorhis
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191
  8 in total

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